2011 Fiscal Year Final Research Report
Elucidation of the roles of tumor necrosis factor and chemokines in inflammation-associated carcinogenesis
| Project/Area Number |
21390117
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kanazawa University |
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Principal Investigator |
MUKAIDA Naofumi 金沢大学, がん進展制御研究所, 教授 (30182067)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腫瘍 / 炎症 / 微小環境 / ケモカイン / 遺伝子欠損マウス |
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| Research Abstract |
We investigated the pathophysiological roles of chemokines in mouse tumor models. We proved that a chemokine, CCL2, was produced in colon tissues during the course of carcinogenesis process caused by the combined treatment of azoxymethane and dextran sodium sulfate. The produced CCL2 induced the migration of cyclooxygenase-2-expressing macrophages, thereby contributing to the development and progression of carcinomas. Moreover, another chemokine, CCL3, was produced in the same carcinogenesis step and contributed to the establishment of fibrosis in the later phase of the process. On the contrary, we observed that anti-tumor effects after radiofrequency ablation of mouse hepatoma were augmented by an intravenous injection of CCL3, which could trigger the migration of dendritic cells into the ablated sites, thereby inducing a tumor-specific immunity. Thus, in contrast to endogenously produced CCL3, a pharmacological dose of CCL3 may induce tumor-specific immunity by regulating the migratory process of dendritic cells.
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[Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011
Author(s)
Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, and Kaneko S
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Journal Title
Clin Exp Immunol
Volume: 163(2)
Pages: 165-177
DOI
Peer Reviewed
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