2011 Fiscal Year Final Research Report
Analysis of phosphoryl at ionsignals in regulation of stem cell system
Project/Area Number |
21390119
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Osaka University |
Principal Investigator |
KIMURA Tohru 大阪大学, 生命機能研究科, 准教授 (50280962)
|
Co-Investigator(Renkei-kenkyūsha) |
NADA Shigeyuki 大阪大学, 微生物病研究所, 准教授 (50291448)
|
Project Period (FY) |
2009 – 2011
|
Keywords | 幹細胞 / 多能性 / リン酸化シグナル / 生殖細胞 / 再生医学 |
Research Abstract |
Stem cell system is involved in pathological aspects of ti ssues, such as tumorigenesis and aging, as well as in regulation of tissue homeostasis. Tn addition, pluripotent stem cells hold great promise in cell transplantation therapy. Tn this study, we have shown that the phosphorylation signals including Akt signal regulate tumorigenesi s of tissues, acquisition of pluripotency in germl ine cells and induction of iPS(induced pluripotent stem) cells. By manipulation of phosphorylation signal s, we also developed in vitro differentiation system of germ cells from pluripotent stem
|
-
[Journal Article] Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of Tffrogulatory factor 2(Trf2) in trypsinogen5 gene transcription2011
Author(s)
Hayashi H, Kohno T, Yasui K, Murota H, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama. I, Ma. Y, Chua. KJ, Suematsu T, himokawa T, Akira S, Kubo Mak TW, and Matsuyama. T
-
Journal Title
Proc. Natl. Acad. Sci, USA
Volume: 108(46)
Pages: 18766-18771
Peer Reviewed
-
-
[Journal Article] MVH in piRNA processing and gene silencing of retrotransposons2010
Author(s)
Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Kimura T, Nakatsuji N, Noce T, Sasaki H, and Nakano T
-
Journal Title
Genes Dev
Volume: 24(9)
Pages: 887-892
Peer Reviewed
-
-
-
-
-
-
-
-
-
-