2011 Fiscal Year Final Research Report
Molecular Mechanisms underlying a novel form of cell death induced by impaired GDNF signaling
| Project/Area Number |
21390122
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ENOMOTO Hideki 独立行政法人理化学研究所, 神経分化・再生研究チーム, チームリーダー (00360511)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞死 / GDNF / 腸管神経 / カスパーゼ / アポトーシス |
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| Research Abstract |
Investigation of molecular mechanism underlying caspase-independent cell death of enteric neurons triggered by GDNF deprivation(CI DEN) revealed an intrinsic absence of Apaf-1 function in enteric neurons, which appears to account for the lack in morphological hallmark of apoptosis in CIDEN. Genetic manipulation to block CIDEN in vivo did not cause an increased numbers of enteric neurons, suggesting that CIDEN does not occur in the physiological condition. Blocking CIDEN, however, rescued the intestinal aganglionosis in a mouse model for Hirschsprung disease(HSCR, congenital absence of the enteric ganglia), suggesting that CIDEN is central to the pathogenesis of HSCR.
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[Journal Article] Differential RET signaling reponses orchestrate lymphoid and nervous enteric system development2012
Author(s)
Patel A, Harker N, Moreira-Santos L, Ferreira M, Alden K, Foster K, Garefalaki A, Pachnis P, Andrews P, Enomoto H, Milbrandt J, Pachnis V, Coles MC, Kioussis D, Veiga-Fernandes H
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Journal Title
Science Signaling
Volume: (in press)
Peer Reviewed
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[Journal Article] Ret-Dependent Cell Rearrangements in the Wolffian Duct Epithelium Initiate Ureteric Bud Morphogenesis2009
Author(s)
Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F
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Journal Title
Developmental Cell
Volume: 17
Pages: 199-209
Peer Reviewed
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