2011 Fiscal Year Final Research Report
Inhibition of CD4+ T cell function during infection with malaria parasite
Project/Area Number |
21390125
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Parasitology (including Sanitary zoology)
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Research Institution | Nagasaki University |
Principal Investigator |
YUI Katsuyuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90274638)
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Co-Investigator(Kenkyū-buntansha) |
KIMURA Daisuke 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50423637)
MIZUSAKI Hirofumi 長崎大学, 大学院・医歯薬学総合研究科, 助教 (40467957)
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Project Period (FY) |
2009 – 2011
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Keywords | マラリア / 原虫 / T細胞 / 感染防御 / サイトカイン |
Research Abstract |
We investigated mechanisms of the modulation of T cell immune responses during infection with Plasmodium berghei ANKA(PbA). CD4^+ T cells from PbA-infected mice inhibited IL-2 production of other CD4^+ T cells by cytokine-mediated mechanisms. The inhibitory cells were foxp3-activated CD4^+ T cells and were distinct from Tregs. The inhibitory cytokine produced by these CD4^+ T cells was not TGF-b or IL-10, and was identified as a novel T cell producing inhibitory cytokine X.
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Research Products
(20 results)
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[Journal Article] DEN2 16681 strain utilizes specific glycochain of Syndecan-2 proteoglycan as a receptor2012
Author(s)
Okamoto, K., Kinoshita, H., del Camen Parquet, M., Rawekiensya, M., Kimura, D., Yui, K., Alimul Islam, M., Hasebe, F., Morita, K.
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Journal Title
J. Gen. Virol.
Volume: 93
Pages: 761-770
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[Journal Article] Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel2011
Author(s)
Shindo, H., Yasui, K., Yamamoto, K., Honma, K., Yui, K., Kohno, K., Ma, Y. Chua, K. J., Kubo, Y., Aihara, H., Ito, T., Nagayasu, T., Matsuyama, T., Hayashi, H.
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Journal Title
Cytokine
Volume: 56(3)
Pages: 564-572
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[Journal Article] Characterization of waves of leukocyte recruitment to the lung allograft and the effect of CTLA4-Ig2011
Author(s)
Taguchi, T., Inamura, Y., Honma, K., Kimura, D., Miyakoda M., Miyazaki, T., Tsuchiya, T. Yamasaki, N., Tagawa, T., Nagayasu, T., Yui, K.
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Journal Title
Acta Medica Nagasakientia
Volume: 56
Pages: 27-34
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[Journal Article] The JMJD3-IRF4 axis regulates M2 macrophage polarization and host response against helminth infection2010
Author(s)
Satoh, T., Takeuchi, O., Vnadenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., Honma, K., Matsuyama, T., Yui, K., Tsujimura, T., Standley, D. M., Nakanishi, K., Nakai, K., Akira, S.
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Journal Title
Nature Immunol.
Volume: 11(10)
Pages: 936-944
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