2011 Fiscal Year Final Research Report
The roles of innate T cells in bacterial infection
| Project/Area Number |
21390130
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Bacteriology (including Mycology)
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Hsakata 九州大学, 生体防御医学研究所, 准教授 (20363369)
SHBATA Kensuke 九州大学, 生体防御医学研究所, 助教 (50529972)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 感染免疫 |
|---|
| Research Abstract |
Innate T cells are defined as(1) cells that develop in the thymus under different signal pathways from conventional T cells,(2) cells that express an activated and/or memory T-cell phenotype and exhibit immediate effector functions.(3) cells that includd y6 T cells, memory phenotype(MP) CD44^<hlgh> CD62L^<low> CD4^+ and CD8^+ T cells. Innate y6 T cells already differentiate into interleukin(IL)-li-producing cells within the fetal thymus. HESl plays a role in regulating differentiation of IL-li producing y6 T cells in thymus and" naturally occurring y6 T cells" play a protective role in the lung at very early stage after systemic infection with Mycobacterium bovis BCG. We further found that IL-lsKo mice are highly susceptible to Listeria monocytogenes and bystander proliferation of the innate CD8^+ T cells induced by L. monocytogenes was impaired in the absence of IL-Is. These results suggested that IL-Is plays an important role in the maintenance and functions of innate CD8^+ T cells, which participate in innate host defense mechanisms. We also found that CDsoLKO mice are highly susceptible to L. monocytogenes infection accompanied by a marked decrease in innate MP IFN-y+ CD4+ T cells at an early stage after infection. These findings suggested that a potential role of CDsoL in activation of innate CD4^+ T cells at an early stage after bacterial in fection.
|
-
-
-
-
-
[Journal Article] Notch-Hesl pathway is required for thedevelopment of ILliproducing y8 T cells2011
Author(s)
Shibata K., Yamada H., Sate T., Dejima S., Nakamura M., , Ikawa T., Hara H., Yamasaki S., Kageyama R., Iwakura Y., Kawamoto H., Ton H. and Yoshikai Y.
-
Journal Title
Blood
Volume: 118
Pages: 586-93
-
-
-
[Journal Article] Selective control of type I IFN induction by the Rae activator DOCK2 during TLRmediated plasmacytoid dendritic cell activation2010
Author(s)
otoh K., Tanaka Y., Nishikimi A., Nakamura R., Yamada H., Maeda N., Ishikawa T., Hoshino K., Uru no T., Cao Q, Higashi S., Kawaguchi Y, Enjoji M, Takayanagi, R., Kaisho T. Yoshikai, Y. and Fukui Y.
-
Journal Title
J. Exp. Med
Volume: 207
Pages: 721-30
-
-
-
-
-
-
-
[Journal Article] Donor CD4 T cells are critical in allogeneic stem cell transplantation against murine solid tumor2009
Author(s)
Kamiryo Y., , Eta M., Yamada H., Harano M., Yajima T., Harano M., Tatsugami K., Hamaguchi M., Takeuchi A., Naito S., and Yoshikai Y.
-
Journal Title
Cancer Research
Volume: 69
Pages: 5151-8
-
-
-
-
-
[Journal Article] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis2009
Author(s)
Oyamada A., Ikebe H., Itsumi M., Saiwai H., Okada, S., Shimoda, K., Iwakura, Y., Nakayama, K., Iwamoto, Y., Yoshikai, Y. and Yamada H.
-
Journal Title
J. Immuol
Volume: 183
Pages: 7539-46
-
[Journal Article] Direct recognition of mycobacterial cord factor, trehalose dimycolate, by C-type lect in Mincle2009
Author(s)
Ishikawa E., Ishikawa T., Marita Y., Toyonaga K., Yamada H., Takeuchi 0., Akira S., Kinoshita T., Yoshikai Y. and Yamasaki S.
-
Journal Title
J. Exp. Med
Volume: 206
Pages: 2879-88
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
