2011 Fiscal Year Final Research Report
Comprehensive analysis of Bordetella type III effectors
| Project/Area Number |
21390133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
ABE Akio 北里大学, 大学院・感染制御科学府, 教授 (50184205)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAMATSU Kanna 北里大学, 北里生命科学研究所, 助手 (90458745)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 百日咳 / ボルデテラ属細菌 / 気管支敗血症菌 / III型分泌装置 / エフェクター |
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| Research Abstract |
Bordetella species including Bordetella pertussis deliver effectors into host cells via a type III secretion system(T3SS). Effector-host factor interaction alters host physiological conditions, leading to disease process. In this study, we identified and analyzed new effector(designated BspR) in Bordetella bronchiseptica. BspR effector was translocated into the nucleus, and then interacted with hnRNP H. Interestingly, BspR was a global transcriptional regulator for T3SS and other virulence factors in bacterial cytosol.
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