2011 Fiscal Year Final Research Report
Studies on cross-reactive antibodies to multiple subtypes of influenza virus henagglutinin induced by mucosal immunization
| Project/Area Number |
21390134
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAKADA Ayato 北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Yasuhiko 北海道大学, 人獣共通感染症リサーチセンター, 教授 (90206540)
ITO Kimihito 北海道大学, 人獣共通感染症リサーチセンター, 教授 (60396314)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 感染防御 / ワクチン |
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| Research Abstract |
Currently used parenteral influenza vaccines induce serum IgG antibody response against hemagglutinin (HA), but do not protect primary infection in the respiratory tissues. In addition, vaccine-induced antibodies are not cross-reactive to viruses with different HA subtypes from that of vaccine strains. In this study, we found that intranasal immunization of mice with inactivated influenza viruses induced antibodies cross-reactive to multiple HA subtypes. Furthermore, it was suggested that IgA antibodies associated with mucosal immunity played an important role in heterosubtypic inhibition of virus replication.
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Research Products
(32 results)
