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2011 Fiscal Year Final Research Report

Identification and characterization of host factors required for virus replication

Research Project

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Project/Area Number 21390136
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YAMAOKA Shoji  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90263160)

Project Period (FY) 2009 – 2011
Keywordsウイルス複製 / ウイルス / 細胞因子 / HIV / 複製
Research Abstract

Two host cell factors were identified that regulate the replication of HIV-1, the causative agent of AIDS. One is involved in the reverse transcription stage, while the other is potentially involved in the nuclear translocation stage. The fact that these host factors did not affect cell growth implicates these factors as a potential therapeutic target for treatment of HIV-1-infected individuals.

  • Research Products

    (4 results)

All 2012 2010 2009 Other

All Presentation (3 results) Remarks (1 results)

  • [Presentation] ヒトCPSF6のC末欠損体はHIV-1感染後の逆転写効率に影響をおよぼす因子である2012

    • Author(s)
      堀 恭徳, 武内 寛明, 佐久間 龍太, 山岡 昇司
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20121100
  • [Presentation] ヒトCPSF6-375はHIV-1の逆転写産物精製を阻害する2010

    • Author(s)
      堀 恭徳, 大迫 美穂, 山岡 昇司
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      20101100
  • [Presentation] HIV-1複製を阻害するcDNAの単離と解析2009

    • Author(s)
      山岡昇司
    • Organizer
      第57回ウイルス学会
    • Place of Presentation
      東京
    • Year and Date
      20091000
  • [Remarks]

    • URL

      http://molv.org/index.html

URL: 

Published: 2015-03-12  

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