2011 Fiscal Year Final Research Report
Development of novel therapy against the transcriptional regulatory mechanism of human immunodeficiency virus(HIV).
| Project/Area Number |
21390142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Nagoya City University |
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Principal Investigator |
OKAMOTO Takashi 名古屋市立大学, 大学院・医学研究科, 教授 (40146600)
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| Co-Investigator(Kenkyū-buntansha) |
ASAMITSU Kaori 名古屋市立大学, 大学院・医学研究科, 講師 (20381783)
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| Project Period (FY) |
2009 – 2011
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| Keywords | HIV-1 / NF-κB / Tat / Cyclin T1 |
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| Research Abstract |
In this study, we have been exploring the step of viral transcription that is the rate-determining step of viral replication in order to provide vital information for the development of novel anti-HIV strategy. We have clarified the interaction between Tat and CycT1 at the AA side chain level by creating a number of CycT1 mutants in which critical AA resides were substituted by Ala based recently published 3D structure of Tat-CycT1 molecular complex. These findings have provided scientific basis for the development of Tat inhibitors.
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