2011 Fiscal Year Final Research Report
Identification of mechanism underlying transcriptional regulation in microenvironment formation essential for immunological self-tolerance
| Project/Area Number |
21390148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Jun-ichiro 東京大学, 医科学研究所, 教授 (70176428)
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| Research Collaborator |
SHIMO Usuke 東京大学, 新領域創成科学科, 大学院生
HSHIMA Aisuke 東京大学, 新領域創成科学科, 大学院生
HINZAWA Miho 東京大学, 新領域創成科学科, 大学院生
KIYAMA Noubuko 東京大学, 医科学研究所, 客員研究員
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| Project Period (FY) |
2009 – 2011
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| Keywords | 免疫寛容 / 自己免疫 / 胸腺 |
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| Research Abstract |
T cells play critical roles in immune responses. During the development of T cells in the thymus, T cells recognizing self-antigens are eliminated, thereby preventing the onset of autoimmune diseases. Medullary thymic epithelial cells (mTECs) ectopically express self-antigen that are normally expressed in tissue specific manner. Our study identified transcription factors regulating gene expressions in mTEC, thereby modulating the differentiation of mTECs.
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[Journal Article] RANK signaling induces interferon-stimulated genes inthe fetal thymic2011
Author(s)
Ohshima D., Qin J., Konno H., Hirosawa A., Shiraishi T., Yanai H., Shimo Y., Shinzawa M., Akiyama N., Yamashita R., Nakai K., Akiyama T*(corresponding author), and
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 408
Pages: 530-536
DOI
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[Journal Article] Okumura K., Kamradt T., Saito H., Nakae S. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage2011
Author(s)
Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M.,
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Journal Title
Plos One
Volume: 6
Pages: e18404
DOI
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[Journal Article] Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma2011
Author(s)
Mouri Y., Yano M., Shinzawa M., Shimo Y., Hirota F., Nishikawa Y, Nii T., Kiyonari H., Abe T., Uehara H., Izumi K., Tamada K., Chen L., Penninger JM., Inoue J., Akiyama T*(corresponding author), and Matsumoto M.
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Journal Title
J. Immunol.
Volume: 186
Pages: 5047-57
DOI
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[Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF-〓B pathway.2010
Author(s)
ando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J and Iba H.
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 21951-60
DOI
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[Journal Article] Human lactoferrin activates NF-kB through Toll-like receptor 4 (TLR4) pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling2010
Author(s)
Ando K, Hasegawa K, Shindo K, Furusawa T, Fujino T, Kikugawa K, Nakano H, Takeuchi O, Akira S, Akiyama T, Gohda J, Inoue J, Hayakawa M.
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Journal Title
FEBS J.
Volume: 277
Pages: 2051-2066
DOI
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