2011 Fiscal Year Final Research Report
Elucidation of the mechanism underlying immune cell trafficking dependent on lysophospholipid signaling
| Project/Area Number |
21390151
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASAKA Haruko 大阪大学, 医学系・研究科, 助教 (70379246)
UMEMOTO Eiji 大阪大学, 医学系・研究科, 助教 (90452440)
BAI Zhongbin 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (10512840)
VERJAN GARCIA Noel 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (90533216)
CAI Linjun 大阪大学, 免疫学フロンティア研究センター, 特任研究員(常勤) (90584079)
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| Project Period (FY) |
2009 – 2011
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| Keywords | リンパ球ホーミング / 血管内皮細胞 / リゾリン脂質 / 細胞接着 / ケモカイン |
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| Research Abstract |
We analyzed the role of a lysophospholipase D, autotaxin(ATX), which produces a bioactive lipid mediator, lysophospholipid(LPA). ATX is highly expressed in the high endothelial venules(HEVs) that mediate lymphocyte trafficking into lymph nodes. We found that ATX expression is highly correlated with lymphocyte extravasation at HEVs and that inhibition of ATX and LPA receptors resulted in strong impairment of lymphocyte trafficking into lymph nodes. LPA abrogated this suppression. These data strongly suggest that the ATX/ LPA axis is a positive regulator of lymphocyte extravasation at HEVs.
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Research Products
(25 results)
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[Journal Article] Novel regulators of lymphocyte trafficking across high endothelial venules2011
Author(s)
Umemoto, E., Hayasaka, H., Bai, Z., Cai, L., Yonekura, S., Peng, X., Takeda, A., Tohya, K. & Miyasaka, M.
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Journal Title
Crit. Rev. Immunol.(Review)
Volume: 312
Pages: 147-169
Peer Reviewed
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[Journal Article] (equal contribution):: Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and-independent manners2010
Author(s)
*Ebisuno, Y., * Katagiri, K., Katakai, T., Ueda, Y., Nemoto, T., Inada, H., Nabekura, J., Okada, T., Kannagi, R., Tanaka, T., Miyasaka, M., Hogg, N. & Kinashi, T
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Journal Title
Blood
Volume: 115
Pages: 804-814
Peer Reviewed
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[Journal Article] (equal contribution): CXC chemokine ligand 12 promotes CCR7-dependent naive T-cell trafficking to lymph nodes and Peyer' s patches2009
Author(s)
Bai, Z., * Hayasaka, H., Kobayashi, M., Li, W., Guo, Z., Jang, M. H., Kondo, A., Choi, B., Iwakura, Y. & Miyasaka, M
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Journal Title
J. Immunol.
Volume: 182
Pages: 1287-1295
Peer Reviewed
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