2011 Fiscal Year Final Research Report
Regulation of CARMA1 signaling and its role in immune homeostasis
| Project/Area Number |
21390153
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAKAWA Hideki かずさDNA研究所, 主任研究員 (80372746)
FURUE Masutaka 九州大学, 医学研究院, 教授 (70134583)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 抗原認識 / リンパ球 / 獲得免疫 / 免疫寛容・自己免疫 |
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| Research Abstract |
We demonstrated that SH3-GUK interactions in CARMA1 is essential for NF-κB activation through antigen receptors by regulating multimerization CARMA1 that controls formation of NF-κB signalosome at immunological synapse. However, lack of this interaction in aged mice developed autoimmune-like skin lesions with hyper-IgE due to an aberrant Th2 response. Thus, SH3-GUK interactions of CARMA1 play an important role in peripheral T cell homeostasis through antigen receptors.
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