2011 Fiscal Year Final Research Report
Molecular mechanism of T cell development in Notch signal mediated nitch
| Project/Area Number |
21390154
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Juntendo University |
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Principal Investigator |
HABU Sonoko 順天堂大学, 医学部, 客員教授 (30051618)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Keiko 順天堂大学, 大学院・医学研究科, 助教 (20053374)
SATAKE Masanobu 東北大学, 加齢医学研究所, 教授 (50178688)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 免疫学 / 胸腺ノッチ / T細胞分化 / ノッチシグナル |
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| Research Abstract |
In this study, we showed that in theT cell developing pathway, GATA3 and Runx1, T cell specific transcription factors, are induced to express correlatively to Notch receptor on immature T cell in the thymus. Notch ligand required for T cells development is also characterized. The over-expression of these transcription factors impaired the early stage developing pathway. Collectively, developing stage specific Notch signaling is suggested regulate the expression of both transcription factors. We also established human Notch L transgenic mice.
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[Journal Article] Runx1 deficiency in CD4+T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells2012
Author(s)
Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai R, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, and Satake M
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Journal Title
J Immunol
Volume: 188
Pages: 5408-5420
Peer Reviewed
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[Journal Article] Over-expression of Runxtranscription factor impairs the development of thymocytes from the double-negative to double-positive stages2010
Author(s)
Wong WF, Nakazato M, Watanabe T, Kohu K, Ogata T, Yoshida N, Sotomaru Y, Ito M, Araki K, Telfer J, Fukumoto M, Suzuki D, Sato T, Hozumi K, Habu S, Satake M
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Journal Title
Immunology
Volume: 130
Pages: 243-253
Peer Reviewed
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[Journal Article] Development of monoclonal antibodies for analyziand hematopoietic systems of common marmoset2009
Author(s)
Kametan i Y, Suzuki D, Kohu K, Satake M, Suemizu H, Sasaki E, Ito T, Tamaoki N, Mizushima T, Ozawa M, Tani K, Kito M, Arai H, Koyanagi A, Yagita H, Habu S
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Journal Title
Exp Hematol
Volume: 37
Pages: 1318-1329
Peer Reviewed
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[Journal Article] Generation of transgenic non-human primates with germline transmission2009
Author(s)
Sasaki E, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, Tomioka I, Sotomaru Y, Hirakawa R, Eto T, Shiozawa S, Maeda T, Ito M, Ito R, Kito C, Yagihashi C, Kawai K, Miyoshi H, Tanioka Y, Tamaoki N, Habu S, Okano H, Nomura T
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Journal Title
Nature
Volume: 459
Pages: 523-527
Peer Reviewed
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[Journal Article] Involvement of PU. 1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter
Author(s)
Baba Y, Maeda K, Yashiro T, Inage E, Niyonsaba F, Hara M, Suzuki R, Ohtsuka Y, Shimizu T, Ogawa H, Okumura K, and Nishiyama C
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Journal Title
Allergol Int
Volume: (in press)
Peer Reviewed
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