2011 Fiscal Year Final Research Report
The study of molecular mechanism and new therapeutic strategy for the pathogenesis of inflammatory pulmonary di sease
| Project/Area Number |
21390172
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUDO Tatsuhiko 理化学研究所, 化合物ライブラリー評価研究チーム, 専任研究員 (30260227)
SUGIYMA Fumihiro 筑波大学, 人間総合科学研究科, 准教授 (90226481)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 炎症性肺疾患 / 慢性閉塞性肺疾患 / 間質性肺炎 / p38 / 肺胞II型上皮細胞 |
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| Research Abstract |
To put the molecular mechanism for pathogenesis of inflammatory pulmonary diseases to practical use, the following studies were performed. (1) Focusing on p38 which plays a central role in various inflammatory responses, one of mitogen-activated protein kinase (MAPK), we tried to produce transgenic mice exhibiting p38 activation in tetracycline-dependent and site (type II alveolar epithelial cell: AECII)-specific manners. (2) We confirmed that severity of bleomycin-induced interstitial pneumonia/pulmonary fibrosis is clearly dependent on the degree of p38 activation in AECII and that IL-6 produced from AECII plays a crucial role in the pathogenesis as a trigger. (3) We induced chronic obstructive pulmonary disease (COPD) in mice and comprehensively estimated plausible candidate molecules in COPD.
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[Journal Article] N-type calcium channel in the pathogenesis of experimental autoimmune encephalomyelitis2010
Author(s)
Tokuhara N, Namiki K, Uesugi M, Miyamoto C, Ohgoh M, Ido K, Yoshinaga T, Yamauchi T, Kuromitsu J, Kimura S, Miyamoto N Kasuya Y
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Journal Title
J. Biol. Chem
Volume: vol.285
Pages: 3329-33306
DOI
Peer Reviewed
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[Presentation] EAEにおけるp38の関与様式2011
Author(s)
並木香奈, 松永博文, 石田純治, 徳原直紀, 上杉麻衣, 須藤龍彦, 萩原昌彦, 深水昭吉, 木村定雄, 粕谷善俊
Organizer
第84回日本薬理学会年会
Place of Presentation
横浜(震災により中止)
Year and Date
20110300
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[Presentation] ブレオマイシン誘導性間質性肺炎成立におけるp38MAPKの役割2010
Author(s)
粕谷善俊, 杉山文博, 松尾祐志, 並木香奈, 石田純治, 桑木共之, 須藤龍彦, 柴田さゆり, 萩原昌彦, 巽浩一郎, 深水昭吉, 木村定雄
Organizer
第83回日本薬理学会年会
Place of Presentation
大阪
Year and Date
2010-03-17
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