2011 Fiscal Year Final Research Report
Elucidation of neuroprotective mechanisms of low molecular weight compounds
| Project/Area Number |
21390175
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
AKAIKE Akinori 京都大学, 大学院・薬学研究科, 教授 (80135558)
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| Co-Investigator(Kenkyū-buntansha) |
KUME Toshiaki 京都大学, 大学院・薬学研究科, 准教授 (10303843)
IZUMI Yasuhiko 京都大学, 大学院・薬学研究科, 助教 (60456837)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳神経疾患 / 生体分子 / 薬理学 |
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| Research Abstract |
We examined the pharmacological effects of serofendic acid, a low molecular weight substances isolated from fetal bovine serum. We revealed that serofendic acid had a protective effect against toxicity induced by amyloidβprotein and serofendic acid significantly reduced infarct volume in rat myocardial infarction model. In addition, we examined the neuroprotective mechanism of nicotinic acetylcholine. We showed that donepezil, an inhibitor of acetylcholinestrase, reduced the increase in the intracellular concentration of calcium induced by glutamate.
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Research Products
(22 results)
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[Journal Article] Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide2011
Author(s)
Kurokawa Y, Sekiguchi F, Kubo S, Yamasaki Y, Matsuda S, Okamoto Y, Sekimoto T, Fukatsu A, Nishikawa H, Kume T, Fukushima N, Akaike A, Kawabata A.
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Journal Title
Biochem Biophys Res Commun
Volume: vol.414
Pages: 727-732
DOI
Peer Reviewed
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[Journal Article] HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats2011
Author(s)
Ohnishi M., Katsuki H., Fukutomi C., Takahashi M., Motomura M., Fukunaga M., Matsuoka Y., Isohama Y., Izumi Y., Kume T., Inoue A., and Akaike A.
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Journal Title
Neuropharmacology
Volume: vol.61
Pages: 975-980
DOI
Peer Reviewed
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[Journal Article] Na+/Ca2+ exchanger inhibitors inhibit neurite outgrowth in PC12 cells2011
Author(s)
Oda, T., Kume, T., Izumi, Y., Ishihara, K., Sugimoto, H., Akaike, A.
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Journal Title
J. Pharmacol. Sci
Volume: vol.116
Pages: 128-131
DOI
Peer Reviewed
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[Journal Article] Assessment of pharmacy students' communication competence using the roter interaction analysis system during objective structured clinical examinations2011
Author(s)
Kubota, Y., Yano, Y., Seki, S., Takada, K., Sakuma, M., Morimoto, T., Akaike, A. and Hiraide, A.
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Journal Title
Am. J. Pharm. Educ
Volume: vol.75
Pages: 1-6
URL
Peer Reviewed
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[Presentation] グリチルリチンによるHMGB1活性阻害を介した脳出血誘発トロンビン毒性の制御2011
Author(s)
大西正俊, 香月博志, 福富千温, 高橋円香, 本村美怜, 福永瑞季, 松岡康裕, 磯濱洋一郎, 泉安彦, 久米利明, 井上敦子, 赤池昭紀
Organizer
第120回日本薬理学会近畿部会
Place of Presentation
ホテルグランビア京都(京都府)
Year and Date
2011-11-11
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[Presentation] Mechanisms of neuroprotection by donepezil pretreatment via nicotinic acetylcholine receptor.2011
Author(s)
Takada-Takatori, Y., Kume, T., Izumi, Y., Fujii, T., Sugimoto, H. and Akaike, A.
Organizer
International Receptor Symposium
Place of Presentation
京都大学(京都府)
Year and Date
2011-04-01
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