Development of Pharmacogenomics in Clinical Oncology

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390182
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Nagasaki University
• Principal Investigator: KAMIHIRA Shimeru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80108290)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Hiroo 長崎大学, 病院, 講師 (00398166) ; YAMADA Yasuaki 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (60145232)
• Project Period (FY): 2009 – 2011
• Keywords: 腫瘍検査学

Research Abstract

Now, 30% of people are death by cancer and 70% of humans are said to be once troubled with cancer in the future near aging society. therefore, the thing for which promotion of Personalized Oncology called ideal medical model is aimed at-people-it wishes widely. Especially simultaneously with evaluation of the immunity character characteristic(Immunophenotype) of the position of a clinical examination to" cancer cell, or the gene characteristic(Cytogenetic), it is the constitutional characteristic(germ-line-genes information) and the tumor genome characteristic of an individual. It is made to meet and genomic test system which can contribute to development of Personalized Oncology simultaneously is built. The part was carried out for the purpose of things.

Research Products

• [Journal Article] Paradoxical expression of IL-28B mRNA in peripheral blood in human T-cell leukemia virus Type-1 mono-infection and Co-infection with hepatitis C Virus (2012)
  • Author(s): Kamihira S, Usui T, Ichikawa T, Uno N, Morinaga Y, Mori S, Ngai K, Sasaki D, Hasegawa H, Yanagihara K, Honnda T, Ymada Y, Iwanaga M, Kanematu T, Nkao K
  • Journal Title: Epub ahead of print Volume: Virol J 9(1) Pages: 40
• [Journal Article] Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa (2012)
  • Author(s): Itonaga H, Tsushima H, Hata T, Matsuo E, Imanishi D, Imaizumi Y, Kawaguchi Y, Fukushima T, Doi Y, Mori S, Kamihira S, Tomonaga M, Miyazaki Y
  • Journal Title: Int J Hematol Volume: 95(2) Pages: 209-13
• [Journal Article] Nationwide survey of adult T-cell leukemia/ lymphoma(ATL) in Japan (2011)
  • Author(s): Yamada Y, Atogami S, Hasegawa H, Kamihira S, Soda M, Satake M, Yamaguchi K
  • Journal Title: Rinsho Ketsueki Volume: 52(11) Pages: 1765-71
• [Journal Article] Suppressor of cytokine signal 3 and IL28 genetic variation predict the viral response to peginterferon and ribavirin (2011)
  • Author(s): Miyaaki H, Ichikawa T, Yatsuhashi H, Taura N, Miuma S, Usui T, Mori S, Kamihira S, Tanaka Y, Mizokami M, Nakao K
  • Journal Title: Hepatol Res Volume: 41(12) Pages: 1216-1222
• [Journal Article] Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/ lymphoma cells (2011)
  • Author(s): Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
  • Journal Title: Leuk Lymphoma Volume: 52(6) Pages: 1108-17
• [Journal Article] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/ lymphoma cells via activation of a novel RAIDD-caspase-2 pathway (2011)
  • Author(s): Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
  • Journal Title: Leukemia Volume: 25(4) Pages: 575-87
• [Journal Article] leukemia/ lymphoma as a target for epigenetic therapy (2011)
  • Author(s): Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
  • Journal Title: Haematologica Volume: 96(5) Pages: 712-9
• [Journal Article] Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis (2011)
  • Author(s): Hirai M, Kadowaki N, Kitawaki T, Fujita H, Takaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamihira S, Miyachi Y, Uchiyama T
  • Journal Title: Blood Volume: 117(2) Pages: 500-9
• [Journal Article] Defective human T-lymphotropic virus type 1 provirus in asymptomatic carriers (2011)
  • Author(s): Takenouchi H, Umeki K, Sasaki D, Yamamoto I, Nomura H, Takajo I, Ueno S, Umekita K, Kamihira S, Morishita K, Okayama A
  • Journal Title: Int J Cancer Volume: 128(6) Pages: 1335-43
• [Journal Article] Intra-and inter-laboratory variability in human T-cell leukemia virus type-1 proviral load quantification using real-time polymerase chain reaction assays : a multi-center study (2010)
  • Author(s): Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K, Watanabe T
  • Journal Title: Cancer Sci Volume: 101(11) Pages: 2361-7
• [Journal Article] Human T-cell leukemia virus type I(HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers : a nationwide prospective study in Japan (2010)
  • Author(s): Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi Kq
  • Journal Title: Joint Study on Predisposing Factors of ATL Development investigators, Blood Volume: 116(8) Pages: 1211-9
• [Journal Article] Long-term study of indolent adult T-cell leukemia-lymphoma (2010)
  • Author(s): Takasaki Y, Iwanaga M, Imaizumi Y, Tawara M, Joh T, Kohno T, Yamada Y, Kamihira S, Ikeda S, Miyazaki Y, Tomonaga M, Tsukasaki K
  • Journal Title: Blood Volume: 115(22) Pages: 4337-43
• [Journal Article] CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells (2010)
  • Author(s): Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y
  • Journal Title: J Biol Chem Volume: 285(20) Pages: 15511-22
• [Journal Article] Trends in HTLV-1 prevalence and incidence of adult T-cell leukemia/ lymphoma in Nagasaki, Japan (2010)
  • Author(s): Koga Y, Iwanaga M, Soda M, Inokuchi N, Sasaki D, Hasegawa H, Yanagihara K, Yamaguchi K, Kamihira S, Yamada Y
  • Journal Title: J Med Virol Volume: 82(4) Pages: 668-74
• [Journal Article] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma (2010)
  • Author(s): Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M, Ueda R
  • Journal Title: J Clin Oncol Volume: 28(9) Pages: 1591-8
• [Journal Article] First Japanese patient treated with parathyroid hormone peptide immunization for refractory hypercalcemia caused by metastatic parathyroid carcinoma (2010)
  • Author(s): Horie I, Ando T, Inokuchi N, Mihara Y, Miura S, Imaizumi M, Usa T, Kinoshita N, Sekine I, Kamihara S, Eguchi K
  • Journal Title: Endocr J Volume: 57(4) Pages: 287-92
• [Journal Article] Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopenia (2009)
  • Author(s): Yamada Y, Okada M, Kamitamari A, Moriuchi H, Yanai M, Hano O, Tsukasaki K, Tsuruda K, Hasegawa H, Yanagihara K, Kamihira S
  • Journal Title: Intern Med Volume: 48(22) Pages: 1967-71
• [Journal Article] Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells (2009)
  • Author(s): Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S
  • Journal Title: Leukemia Volume: 23(11) Pages: 2090-101
• [Journal Article] Elevation of serum KL-6 glycoprotein or surfactant protein-D in adult T-cell leukemia with distinct pulmonary complications (2009)
  • Author(s): Osaka A, Yanagihara K, Yamada Y, Hasegawa H, Inokuchi N, Hayashi T, Komoda M, Nakamura S, Aoyama M, Sawada T, Kamihira S
  • Journal Title: Tohoku J Exp Med Volume: 218(2) Pages: 99-105
• [Journal Article] High-resolution melting analysis for a reliable and two-step scanning of mutations in the tyrosine kinase domain of the chimerical bcr-abl gene (2009)
  • Author(s): Doi Y, Sasaki D, Terada C, Mori S, Tsuruda K, Matsuo E, Miyazaki Y, Nagai K, Hasegawa H, Yanagihara K, Yamada Y, Kamihira S
  • Journal Title: Int J Hematol Volume: 90(1) Pages: 37-43
• [Journal Article] Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations (2009)
  • Author(s): Kamihira S, Terada C, Sasaki D, Yanagihara K, Tsukasaki K, Hasegawa H, Yamada Y
  • Journal Title: Eur J Haematol Volume: 82(4) Pages: 301-7
• [Journal Article] A novel role of serum cytochrome c as a tumor marker in patients with operable cancer (2009)
  • Author(s): Osaka A, Hasegawa H, Yamada Y, Yanagihara K, Hayashi T, Mine M, Aoyama M, Sawada T, Kamihira S
  • Journal Title: J Cancer Res Clin Oncol Volume: 135(3) Pages: 371-7
• [Journal Article] Serum cytochrome c to indicate the extent of ongoing tumor cell death (2009)
  • Author(s): Osaka A, Hasegawa H, Tsuruda K, Inokuchi N, Yanagihara K, Yamada Y, Aoyama M, Sawada T, Kamihira S
  • Journal Title: Int J Lab Hematol Volume: 31(3) Pages: 307-14
• [Presentation] Overexpression of enhancer of zeste homolog 2 with trimelthylation of lysine 27 on histone H3 in ATL as a target for epigenetic therapy (2010)
  • Author(s): Sasaki D
  • Organizer: IJH
  • Place of Presentation: Kyoto
  • Year and Date: 2010-10-23
• [Presentation] The Overexpression of Enhancer of Zeste Homologue 2 is Associated with Tumor Proliferation and Aggressive Behavior in Adult T-Cell Leukemia/ Lymphoma (2009)
  • Author(s): Sasaki D, Kamihira S
  • Organizer: ASH American Annual Meeting
  • Place of Presentation: USA
  • Year and Date: 20091200
• [Presentation] 自然の実験系ATLに学ぶ臨床化 (2009)
  • Author(s): 上平憲
  • Organizer: 第49回日本臨床化学会学術集会
  • Place of Presentation: 長崎市
  • Year and Date: 20090918-20
• [Presentation] MDSの形態学的異形性に基づく診断確度区分 (2009)
  • Author(s): 鶴田一人、上平憲
  • Organizer: 日本臨床検査医学会
  • Place of Presentation: 三重
  • Year and Date: 20090000
• [Book] 臨床検査ガイド2009-2010 (2009)
  • Author(s): 上平憲
  • Publisher: 文光堂(東京)
• [Book] 臨床検査カレッジ (2009)
  • Author(s): 上平憲
  • Publisher: 文光堂(東京)