2011 Fiscal Year Final Research Report
Risk assessment of carcinogenicity and fibrogenicity in respiratory systems induced by fibrous and particulate materials
| Project/Area Number |
21390187
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HISANAGA Aomi 愛知教育大学, 保健環境センター, 教授 (90111856)
SHIBATA Eiji 愛知医科大学, 医学部, 教授 (90206128)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 繊維・粒子状物質 / 石綿 / リスク評価 / 発がん / 慢性炎症 / 活性酸素・窒素種 / DNA損傷 / 8-ニトログアニン |
|---|
| Research Abstract |
Inhalation exposure to fibrous and particlate materials induces chronic inflammation in respiratory systems, leading to carcinogenesis and fibrosis. We have demonstrated that inflammation-mediated oxidative/nitrative DNA damage is closely associated with asbestos exposure in animal and human lung tissues. Carbon nanomaterials induced nitrative DNA damage in human lung epithelial cells through cellular internalization. In addition, we demonstrated that molecules involved in tissue fibrosis participate in inflammation-related carcinogenesis using experimental animals and human plasma.
|
-
-
-
-
-
-
-
[Journal Article] Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma
Author(s)
Prakobwong S, Charoensuk L, Hiraku Y, Pinlaor P, Pairojkul C, Mairiang E, Sithithaworn P, Yongvanit P, Khuntikeo N, Pinlaor S
-
Journal Title
Int. J. Cancer
Volume: (掲載決定)
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] Tumor microenvironment & Oncogenesis2010
Author(s)
Hiraku Y, Sakai K, Shibata E, Kamijima M, Hisanaga H, Ma N, Kawanishi S, Murata M.
Organizer
The 10th International Conference of the International Mesothelioma Interest Group
Place of Presentation
Kyoto, Japan
Year and Date
20100831-0903
-
-
-
-
-
-
-
-
