Genome epidemiologic study on lung cancer and inflammation-related genes

2012 Fiscal Year Final Research Report

• Project/Area Number: 21390190
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kyushu University
• Principal Investigator: KIYOHARA Chikako 九州大学, 医学研究院, 講師 (00169963)
• Co-Investigator(Kenkyū-buntansha): NAKANISHI Yoichi 九州大学, 大学院・医学研究院, 教授 (20172356) ; TAKAYAMA Koichi 九州大学, 大学院・医学研究院, 准教授 (50274444) ; HORIUCHI Takahiko 九州大学, 大学院・医学研究院, 准教授 (90219212)
• Project Period (FY): 2009 – 2012
• Keywords: 肺がん / ゲノム疫学 / 遺伝子多型 / 国際共同研究 / 交互作用 / 喫煙 / 炎症

Research Abstract

Chronic inflammation has been implicated in the development of lung cancer. The aims of this study were to evaluate the association between inflammation- related polymorphismsand lung cancer and the modifying effects of the polymorphisms on the association of cigarette smoking with lung cancer risk. We genotyped IL1B -511T>C, IL1B -31C>T, IL1B 3954C>T, IL6 rs1800796, IL10 rs1800871, IL13 rs1800925, T NFA rs1799724, TNFR2 rs1061622, MPO rs2333227, CRPrs2794520, COX2 rs5275, PPARG rs13073869 and PPARG rs4135249 polymorphisms in Japanese.Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). The CRP rs2794520 polymorphism was significantly associated with lung cancer risk (OR for CT genotype vs. TT genotype = 1.59, 95% CI = 1.14 - 2.22; OR for CC genotype vs.TT genotype = 1.92, 95% CI = 1.10-3.38) while other polymorphisms were not. The interactions between either the IL1B -511 T>C, CRP rs2794520 or PPARG rs13073869 polymorphisms and smoking were significant. There were no significant interactions between smoking and either of the remaining polymorphisms. Additional studies are required to clarify the effects of the inflammation-related polymorphisms and the smoking-polymorphism interactions on lung cancer.

Research Products

• [Journal Article] Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium (2012)
  • Author(s): Cote ML, Kiyohara C, et al
  • Journal Title: Eur J Cancer Volume: 48 Pages: 1957-1968
  • DOI: DOI:10.1016/j.ejca.2012.01.038
• [Journal Article] Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population (2012)
  • Author(s): Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
  • Journal Title: J Thorac Oncol Volume: 7 Pages: 954-962
  • DOI: DOI:10.1097/JTO.0b013e31824de30f
• [Journal Article] Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population (2011)
  • Author(s): Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
  • Journal Title: BMC Cancer Volume: 11 Pages: 459
  • DOI: DOI:10.1186/1471-2407-11-459
• [Journal Article] Alcohol consumption and lung cancer risk among Japanese: a meta-analysis (2010)
  • Author(s): Uehara Y, Kiyohara C
  • Journal Title: Fukuoka Acta Med Volume: 101(5) Pages: 101-8
• [Journal Article] Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis (2010)
  • Author(s): Kiyohara C, Takayama K, Nakanishi Y
  • Journal Title: J Nucleic Acids Volume: 14 Pages: 701760
  • DOI: DOI:10.4061/2010/701760
• [Journal Article] Sex differences in lung cancer susceptibility: a review (2010)
  • Author(s): Kiyohara C, Ohno Y
  • Journal Title: Gend Med Volume: 7(5) Pages: 381-401
  • DOI: DOI:10.1016/j.genm.2010.10.002
• [Journal Article] Lung cancer susceptibility and hOGG1 polymorphism: A meta-analysis (2010)
  • Author(s): Kiyohara C, Takayama K, Nakanishi Y
  • Journal Title: Cancers Volume: 2 Pages: 1813-1829
• [Journal Article] Genetic Susceptibility to EnvironmentalCarcinogens group (Agundez JA, Kiyohara C, et al.). Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines (2010)
  • Author(s): Langevin SM, Ioannidis JP, Vineis P, Taioli E
  • Journal Title: Pharmacogenet Genomics Volume: 20 Pages: 586-597
  • DOI: DOI:10.1097/FPC.0b013e32833c3892
• [Journal Article] Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu, and the risk of lung cancer in a Japanese population (2010)
  • Author(s): Kiyohara C, Horiuchi T, Miyake Y, Takayama K, Nakanishi Y
  • Journal Title: Oncol Rep Volume: 23 Pages: 1361-1368
• [Journal Article] International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants (2010)
  • Author(s): Truong T, Kiyohara C, et al
  • Journal Title: Carcinogenesis Volume: 31 Pages: 625-633
  • DOI: DOI:10.1093/carcin/bgq001
• [Journal Article] IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population (2010)
  • Author(s): Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y
  • Journal Title: J Thorac Oncol Volume: 5 Pages: 299-304
  • DOI: DOI:10.1097/JTO.0b013e3181c8cae3
• [Presentation] Influence of genetic polymorphisms of TP53 Arg72Pro and TP53BP1 Asp353Glu and smoking on lung cancer risk (2011)
  • Author(s): Kiyohara C, Horiuchi T, Nakanishi Y
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20111003-05
• [Book] NY (2012)
  • Author(s): Kiyohara C, Washio M. Lung cancer andsmoking habit. Encyclopedia of Cancer, 3rd Edition, Schwab M (ed.)
  • Total Pages: 2088-2094
  • Publisher: Springer-Verlag