2012 Fiscal Year Final Research Report
Development of cancer prevention based on the molecular mechanism against malignant mesothelioma.
| Project/Area Number |
21390192
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SOWA Yoshihiro 京都府立医科大学, 医学研究科, 准教授 (70315935)
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| Co-Investigator(Kenkyū-buntansha) |
TOMOSUGI Mano (HORINKA Mano) 京都府立医科大学, 医学研究科, 助教 (80512037)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 悪性中皮腫 / DNA メチル化 / microRNA / HDAC 阻害剤 |
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| Research Abstract |
In malignant mesothelioma cells, miR-34b/c, which is known as a tumor suppressive microRNA, is suppressed by DNA methylation. Since the combination treatment of DNA methyltransferase inhibitor and histone deacetylase (HDAC) inhibitor abrogated the DNA methylation, we treated malignant mesothelioma cells with the combination. As a result, the combination induced growth arrest, apoptosis and the upregulation of miR-34b/c. These results raise a possibility that the combination treatment of DNA methyltransferase inhibitor and HDAC inhibitor might be useful for the treatment and prevention against malignant mesothelioma.
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