2011 Fiscal Year Final Research Report
Cancer prevention study on the relationship of cancer stem cells biomarker and 8-nitroguanine in cancer tissues
| Project/Area Number |
21390195
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006)
OHNISHI Shiho 鈴鹿医療科学大学, 薬学部, 助手 (80511914)
MA Ning 鈴鹿医療科学大学, 保健衛生学部, 教授 (30263015)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Sumiko 鈴鹿医療科学大学, 薬学部, 准教授 (20378657)
TABATA Tsutomu 三重大学, 大学院・医学系研究科, 准教授 (40252358)
KOBAYASHI Yoshinao 三重大学, 大学院・医学系研究科, 講師 (70378298)
HORIKI Noriyuki 三重大学, 医学部・付属病院, 講師
IIJIMA Katsunori 東北大学病院, 消化器内科, 助教 (60375003)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 8-ニトログアニン / 8-oxodG / DNA損傷 / 炎症 / 感染 / 活性窒素種 / バイオマーカー / がん予防 |
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| Research Abstract |
8-Nitroguanine was formed in Oct3/4-positive stem cells in S. haematobium-associated cystitis and cancer tissues. 8-Nitroguanine and stem cell marker glypican-3 was observed in Barrett's esophagus tissues. In conclusion, inflammation by various facters may increase the number of mutant stem cells, in which nitrative DNA damage occurs, leading to tumor development.
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[Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression2012
Author(s)
Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, Murata M, Kawanishi S
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Journal Title
Biochem Biophys Res Commun
Volume: 421(2)
Pages: 280-5
DOI
Peer Reviewed
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[Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection2011
Author(s)
Ma N, Thanan R, Kobayashi H, Hammam O, Wishahi M, El Leithy T, Hiraku Y, Amro el-K, Oikawa S, Ohnishi S, Murata M, Kawanishi S
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Journal Title
Biochem Biophys Res Commun
Volume: 414(2)
Pages: 344-9
DOI
Peer Reviewed
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[Journal Article] Romidepsin(FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide2010
Author(s)
Mizutani H, Hiraku Y, Tada-Oikawa S, Murata M, Ikemura K, Iwamoto T, Kagawa Y, Okuda M, Kawanishi S
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Journal Title
Cancer Sci
Volume: 101(10)
Pages: 2214-9
DOI
Peer Reviewed
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