2011 Fiscal Year Final Research Report
Molecular epidemiology study on immunogenetic and environmental factors involved in risks of inflammation-associated diseases
| Project/Area Number |
21390199
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | 放射線影響研究所 (2011)
Radiation Effects Research Foundation (2009-2010) |
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Principal Investigator |
HAYASHI Tomonori 放射線影響研究所, 放射線生物学/分子疫学部, 副部長 (70333549)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKACHI Kei 放射線影響研究所, 顧問 (00142117)
KUSUNOKI Yoichiro 放射線影響研究所, 放射線生物学/分子疫学部, 部長 (60333548)
OGAWA Takahiko 放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (90399626)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ゲノム / 放射線 / 炎症 / 生活習慣病 / 分子疫学 / 遺伝子多型 / サイトカイン / ケモカイン |
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| Research Abstract |
(1) The human epidermal growth factor receptor genotype plays a crucial role in assessing individual susceptibility to lung cancer associated with radiation exposure.(2) The genotype NKG2D, related to NK activity, affects hepatitis C virus(HCV) clearance following HCV infection and determination of treatment course if HCV infection persists, with radiation exposure and this genotype involved in development of hepatocellular carcinoma.(3) The genotypes of DNA repair-related gene polymorphisms may contribute to inter-individual differences in susceptibility to radiation-related cancer development.(4) CD14 and IL18 genotypes might be involved in development of colon cancer among A-bomb survivors, and response to radiation might vary according to these genotypes.
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Research Products
(20 results)
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[Journal Article] Associations of ionizing radiation and breast cancer-related serum hormone and growth factor levels in cancer-free female a-bomb survivors2011
Author(s)
Grant EJ, Neriishi K, Cologne JB, Eguchi H, Hayashi T, Geyer SM, Izumi S, Nishi N, Land CE, Stevens RG, Sharp GB, Nakachi K
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Journal Title
Radiat Res
Volume: 176
Pages: 678-687
URL
Peer Reviewed
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[Journal Article] Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis2011
Author(s)
Yoshida K, Ohishi W, Nakashima E, Fujiwara S, Akahoshi M, Kasagi F, Chayama K, Hakoda M, Kyoizumi S, Nakachi K, Hayashi T, Kusunoki Y
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Journal Title
Hum Immunol
Volume: 72
Pages: 821-826
DOI
Peer Reviewed
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