2011 Fiscal Year Final Research Report
Research on the fetal origin of adult disease hypothesis using large scale longitudinal twin-family data
| Project/Area Number |
21390206
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Ishikawa Prefectural Nursing University |
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Principal Investigator |
OOKI Syuichi 石川県立看護大学, 看護学部, 教授 (00303404)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 双生児 / 縦断データ / 胎内環境仮説 / 生殖補助医療 / 生活習慣病 / 遺伝疫学 |
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| Research Abstract |
Fetal Origins of Adult Disease(FOAD) hypothesis was studied using twin sample. Longitudinal twin database from perinatal to adult period was constructed. Next, preliminary genetic epidemiologic analyses were conducted. The influence of assisted reproductive technology and laterality were also analyzed as candidate new marker of perinatal and early life environment. It was suggested that FOAD hypothesis is not necessarily applicable in the same manner as singletons in twins. The reason was not clear whether the problem was based on the weakness of the statistic power or adoption mechanism specific to twins.
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