Independent and combined effects of prevalent vertebral fracture and coronary risk factors on disability-free survival

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390210
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kinki University
• Principal Investigator: IKI Masayuki 近畿大学, 医学部, 教授 (50184388)
• Co-Investigator(Kenkyū-buntansha): KURUMATANI Norio 奈良県立医科大学, 医学部, 教授 (10124877) ; TAMAKI Junko 近畿大学, 医学部, 准教授 (90326356) ; FUJITA Yuki 近畿大学, 医学部, 助教 (10330797) ; SATO Yuho 仁愛大学, 生活学部, 准教授 (10337115)
• Project Period (FY): 2009 – 2011
• Keywords: 骨粗鬆症 / 骨折 / 循環器疾患 / リスク評価

Research Abstract

The present study aimed to clarity risk factors of osteoporotic fractures and the effects of fractures and coronary risk factors on mortality in a population-based cohort of 2159 elderly Japanese men. Predictors for fractures appeared to be low bone density, and those for mortality were older age, higher CRP levels and incident fractures(age-adjusted hazard ratio(HR) of fracture : 17.9, multivariate-adjusted HR : 12.9). Thus, incident clinical fractures appeared to be a potent risk factor for mortality in community-dwelling elderly Japanese men.

Research Products

• [Journal Article] 男性の骨粗鬆症と女性の骨粗鬆症の違い (2011)
  • Author(s): 伊木雅之
  • Journal Title: Clin Calcium Volume: 21 Pages: 1377-83
• [Journal Article] Alcohol intake and bone status in elderly Japanese men : baseline data from the FORMEN study (2011)
  • Author(s): Kouda K, Iki M, Fujita Y, Tamaki J, Yura A, Kadowaki E, Sato Y, Moon JS, Morikawa M, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Bone Volume: 49 Pages: 275-80
  • Peer Reviewed
• [Journal Article] Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population : FORMEN Study (2011)
  • Author(s): Iki M, Tamaki J, Fujita Y, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Osteoporos Int
  • DOI: DOI:10.1007/s00198-011-1600-7
  • Peer Reviewed
• [Journal Article] 男性骨粗鬆症 (2011)
  • Author(s): 伊木雅之
  • Journal Title: Current therapy Volume: 29(2) Pages: 8-12
• [Journal Article] Association between vitamin K intake from fermented soybeans, natto, and bone mineral density in elderly Japanese men : the FORMEN study (2011)
  • Author(s): Fujita Y, Iki M, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Osteoporos Int
  • DOI: DOI:10.1007/s00198-011-1594-1
  • Peer Reviewed
• [Journal Article] Impact of smoking on bone mineral density and bone metabolism in elderly men : The FORMEN Study (2010)
  • Author(s): Tamaki J, Iki M, Fujita Y, Kouda K, Yura A, Kadowaki E, Sato Y, 他4名
  • Journal Title: Osteoporosis Int
  • DOI: DOI:10.1007/s00198-010-1238-x
  • Peer Reviewed
• [Journal Article] Relationship of tooth loss to mild memory impairment and cognitive impairment : findings from the Fujiwara-kyo study (2010)
  • Author(s): Okamoto N, Morikawa M, Okamoto K, Habu N, Iwamoto J, Tomioka K, Saeki K, Yanagi M, Amano N, Kurumatani N
  • Journal Title: Behav Brain Funct Volume: 6 Pages: 77
  • Peer Reviewed
• [Journal Article] Tooth loss is associated with mild memory impairment in the elderly : the Fujiwara-kyo study (2010)
  • Author(s): Okamoto N, Morikawa M, Okamoto K, Habu N, Hazaki K, Harano A, Iwamoto J, Tomioka K, Saeki K, Kurumatani N
  • Journal Title: Brain Res Volume: 1349 Pages: 68-75
  • Peer Reviewed
• [Journal Article] Increasing the number of steps walked each day improves physical fitness in Japanese community-dwelling adults (2010)
  • Author(s): Okamoto N, Nakatani T, Okamoto Y, Iwamoto J, Saeki K, Kurumatani N
  • Journal Title: Int J Sports Med Volume: 31 Pages: 277-82
  • Peer Reviewed
• [Journal Article] Design and baseline characteristics of a prospective cohort study for determinants of osteoporotic fracture in community-dwelling elderly Japanese men : The FORMEN Study (2009)
  • Author(s): Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, et al.
  • Journal Title: BMC Musculoskelet Disord Volume: 10 Pages: 165
  • Peer Reviewed
• [Presentation] GFR estimated with serum creatinine may be misleading in association between subclinical decline in renal function and bone mass in community-dwelling elderly men : FORMEN Study (2011)
  • Author(s): Iki M, et al.
  • Organizer: 3rd Joint Meeting of ECTS & IBMS
  • Place of Presentation: Athens, Greece
  • Year and Date: 20110507-11
• [Presentation] 骨代謝における軽度・中等度腎機能低下の影響～藤原京スタディ男性骨粗鬆症コホート研究～ (2011)
  • Author(s): 藤田裕規、伊木雅之、玉置淳子、甲田勝康、由良晶子、門脇英子、佐藤裕保、文鐘聲、冨岡公子、岡本希、車谷典男
  • Organizer: 日本疫学会
  • Place of Presentation: 札幌市
  • Year and Date: 20110121-22
• [Presentation] HMG-CoA還元酵素阻害剤は骨量低下を抑制するか-藤原京スタディ男性骨折コホート研究の断面検討 (2011)
  • Author(s): 玉置淳子、伊木雅之、藤田裕規、甲田勝康、由良晶子、門脇英子、佐藤裕保、文鐘聲、冨岡公子、岡本希、車谷典男
  • Organizer: 日本疫学会
  • Place of Presentation: 札幌市
  • Year and Date: 20110121-22
• [Presentation] Epideniology of Osteoporosis in Japan (2011)
  • Author(s): Iki M
  • Organizer: The 12th Annual Meeting of the Korean Society of Osteoporosis
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-12-10
• [Presentation] 骨粗鬆症の疫学とそれによる骨折のリスク評価 (2011)
  • Author(s): 伊木雅之
  • Organizer: 第13回日本骨粗鬆症学会
  • Place of Presentation: 神戸市
  • Year and Date: 2011-11-05
• [Presentation] 地域ベースのコホート研究から見た骨折・骨粗鬆症と糖尿病の関連 (2011)
  • Author(s): 伊木雅之
  • Organizer: 徳島大学糖尿病臨床・研究開発センター講演会
  • Place of Presentation: 徳島市
  • Year and Date: 2011-01-24
• [Presentation] 習慣的牛乳飲用は男性高齢者でも高骨密度に関連する-藤原京スタディ男性骨粗鬆症研究 (2010)
  • Author(s): 佐藤裕保、伊木雅之、藤田裕規、玉置淳子、甲田勝康、由良晶子、門脇英子、文鐘聲、冨岡公子、岡本希、車谷典男
  • Organizer: 第69回日本公衆衛生学会
  • Place of Presentation: 東京
  • Year and Date: 20101027-29
• [Presentation] 高齢者における慢性腎臓病有病状況とその循環器リスク要因への影響-藤原京スタディ- (2010)
  • Author(s): 伊木雅之、玉置淳子、藤田裕規、甲田勝康、由良晶子、門脇英子、冨岡公子、岡本希、車谷典男
  • Organizer: 第69回日本公衆衛生学会
  • Place of Presentation: 東京
  • Year and Date: 20101027-29
• [Presentation] Baseline data of a cohort study for determinants of osteoporotic fracture in community-dwelling elderly Japanese men : the Fujiwara-kyo Osteoporosis Risk in Men(FORMEN) Study (2010)
  • Author(s): Masayuki Iki, et al.
  • Organizer: The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
  • Place of Presentation: 越谷市
  • Year and Date: 20100109-10
• [Presentation] 捨て置かれし男性の骨を守ろう!藤原京スタディ男性骨粗鬆症コホート研究の発進 (2009)
  • Author(s): 伊木雅之, 他
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 奈良市
  • Year and Date: 20091021-23
• [Presentation] 納豆摂取による骨密度低下の予防効果～藤原京スタディ男性骨粗鬆症コホート研究～ (2009)
  • Author(s): 藤田裕規, 他
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 奈良市
  • Year and Date: 20091021-23
• [Presentation] 禁煙は骨密度低下の速度を下げる-藤原京スタディ男性骨粗鬆症コホート研究の断面検討 (2009)
  • Author(s): 玉置淳子, 他
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 奈良市
  • Year and Date: 20091021-23
• [Presentation] 適度な飲酒は骨粗鬆症を防ぐ-藤原京スタディ男性骨粗鬆症コホート研究- (2009)
  • Author(s): 甲田勝康, 他
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 奈良市
  • Year and Date: 20091021-23
• [Presentation] 藤原京スタディ男性骨粗鬆症コホート研究の発進 (2009)
  • Author(s): 伊木雅之, 他
  • Organizer: 日本骨粗鬆症学会
  • Place of Presentation: 名古屋市
  • Year and Date: 20091014-16