2012 Fiscal Year Final Research Report
The association of fatty acid composition with pre-clinical biomarkers and asthma
| Project/Area Number |
21390213
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Public health/Health science
|
|---|
| Research Institution | Research Institute, International Medical Center of Japan |
|---|
Principal Investigator |
MIZOUE Tetsuya 独立行政法人国立国際医療研究センター, 臨床研究センター, 部長 (60269074)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATO Masao 九州大学, 大学院・農学研究院, 准教授 (90294909)
|
|---|
| Project Period (FY) |
2009 – 2012
|
| Keywords | 保健栄養 / 脂肪酸組成 / 生活習慣病 / バイオマーカー |
|---|
| Research Abstract |
Fatty acid composition in serum was examined in relation to various biomarkers of metabolic diseases. Serum C-peptide levels were inversely associated with linoleic acid levels and positively with stearic, palmitoleic, and dihomo-γ-linoleic acids. Urinary 8-oxo-7,8-dihydroguanine levels increased with increasing concentrations of n-3 PUFAS, EPA, and DHA, whereas they decreased with increasing concentrations of n-6 PUFA and linoleic acid. Results suggest an important role of fatty acid composition in the pathogenesis of lifestyle-related diseases.
|
-
-
-
-
[Journal Article] High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance.2012
Author(s)
Kurotani K, Sato M, Ejima Y, Nanri A, Yi S, Pham NM, Akter S, Poudel-Tandukar K, Kimura Y, Imaizumi K, Mizoue T
-
Journal Title
Nutr Res
Volume: 32
Pages: 669-675
Peer Reviewed
-
-
-
-
-
-
