2011 Fiscal Year Final Research Report
Investigations on methamphetamine-neurotoxicity by using an animal model
| Project/Area Number |
21390217
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OH Ro 金沢医科大学, 医学部, 講師 (60555051)
TAKEICHI Toshiaki 金沢医科大学, 医学部, 助教 (90460360)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 法医病理学 |
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| Research Abstract |
This study suggests that, in consideration of the neurotoxic effects of methamphetamine(METH) due to oxidative stress, pharmacological intervention on NO synthase may help reduce the monoamine-depleting and apoptosis-inducing effects of methamphetamine and that pretreatment with low-dose METH may be protective against METH neurotoxicity in the midbrain, leading to the suppression of oxidative stress and apoptotic mechanisms, in part via ER stress-related pathways. In the point of view of forensic pathology, an animal model of escalation drug intake and pretraetment of low-dose METH prior to neurotoxic-dose admistration could be useful to investigate the mechanisms involved in neurotoxicity of human METH abusers.
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