2011 Fiscal Year Final Research Report
Investigation on the protective action of androgen on aging and age-related diseases : from cellular senescence to frailty
| Project/Area Number |
21390220
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ETO Masato 東京大学, 医学部附属病院, 特任准教授 (80282630)
OGAWA Sumito 東京大学, 医学部附属病院, 講師 (20323579)
OTA Hidetaka 東京大学, 医学部附属病院, 助教 (20431869)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 長寿 / 老年病 / 男性ホルモン / アンドロゲン / テストステロン |
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| Research Abstract |
This project was conducted to investigate the protective action of androgen on aging and age-related diseases. Clinical studies showed that low plasma androgen levels were associated with metabolic syndrome and atherosclerosis in middle-aged men as well as cognitive impairment, dependence and high mortality in frail elderly men and women. Basic research using cultured cells and animal models revealed the protective action of androgen on aging and the important role of NO and SIRT1 in its process.
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