Analysis of regulatory molecule on vascular aging

2012 Fiscal Year Final Research Report

• Project/Area Number: 21390223
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Osaka University
• Principal Investigator: KATSUYA Tomohiro 大阪大学, 医学系研究科, 特任准教授 (30311757)
• Co-Investigator(Kenkyū-buntansha): NAKAGAMI Hironori 大阪大学, その他の研究科, その他 (20325369) ; MORISHITA Ryuichi 大阪大学, 医学(系)研究科(研究院), その他 (40291439) ; RAKUGI Hiromi 大阪大学, 医学(系)研究科(研究院), 教授 (20252679)
• Project Period (FY): 2009 – 2012
• Keywords: 老化 / インスリン抵抗性

Research Abstract

Here we show SNCA’s function in the glucose metabolism, which is a susceptible gene for Parkinson’s disease. In a transversal study in Japanese population, we found that serum SNCA was strongly inversely correlated with elevated seric insulin resistance indicators. Additionally, SNCA knock-out mice displayed evident alterations in glucose and insulin response during dietary-induced insulin resistance. In this study, we also performed a genome-wide case-control association study in Japanese individuals. The analysis showed that a non-coding SNP in a member of the oxysterol binding proteins, OSBPL10 (oxysterol binding protein like 10), was significantly associated with PAD. We replicated the association in another panel of public medical examinations, andfound that the non-risk allele of this cSNP correlated with a low serum LDL cholesterol levelindependent of age, sex and body mass index.

Research Products

• [Journal Article] Variation in OSBPL10 is associated with dyslipidemia. (2010)
  • Author(s): Koriyama H, Nakagami H, Katsuya T, Akasaka H, Saitoh S, Shimamoto K, Ogihara T, Kaneda Y, Morishita R, Rakugi H.
  • Journal Title: Hypertens Res Volume: 33(5) Pages: 511-4
• [Journal Article] Identification of Evidence Suggestive of an Association with Peripheral Arterial Disease at the OSBPL10 Locus by Genome-Wide Investigation in the Japanese Population. (2010)
  • Author(s): Koriyama H, Nakagami H, Katsuya T, Sugimoto K, Yamashita H, Takami Y, Maeda S, Kubo M, Takahashi A, Nakamura Y, Ogihara T, Rakugi H, Kaneda Y, Morishita R.
  • Journal Title: J Atheroscler Thromb Volume: 17(10) Pages: 1054-62
• [Presentation] コレステロール代謝・輸送系制御機構における細胞機能・老化の解析 (2012)
  • Author(s): 勝谷友宏、郡山弘、中神啓徳、森下竜一
  • Organizer: 第54回日本老年医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-06-29
• [Presentation] Alpha-synuclein is associated with impaired glucose regulation and insulin resistance (2011)
  • Author(s): 中神啓徳
  • Organizer: 第19回血管生物医学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-12-10
• [Book] Dyslipidemia - From Prevention to Treatment, Chapter 7, Functions of OSBP/ORP Family Proteins and Their Relation to Dyslipidemia
  • Author(s): Koriyama H, Nakagami H, Katsuya T, Morishita R