2011 Fiscal Year Final Research Report
The analysis of the predictive marker for the efficacy of the angiogenesis inhibitor for the treatment of hepatocellular carcinoma
| Project/Area Number |
21390225
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Chiba University |
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Principal Investigator |
YOKOSUKA Osamu 千葉大学, 大学院・医学研究院, 教授 (90182691)
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Fumihiko 千葉大学, 大学院・医学研究院, 講師 (70334399)
ARAI Makoto 千葉大学, 医学部附属病院, 助教 (30396684)
TADA Motohisa 千葉大学, 医学部附属病院, 助教 (00554239)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝臓学 |
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| Research Abstract |
(Basic) We explored the mRNA expression of angiogenesis-related or cell proliferation-related genes (total 37 genes) in 26 hepatocarcinoma tissues. Only HIF1α expression was correlated with pathological differentiation, tumor vascularity, and macroscopic vascular invasion. (Clinical)We explored the predictive marker for the treatment efficacy of sorafenib in 54 hepatocellular carcinoma patients and revealed that modified RECIST findings and AFP level were useful for the prediction of the efficacy of the sorafenib treatment.
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[Journal Article] Safety and tolerance of sorafenib in Japanese patients with advanced hepatocellular carcinoma2011
Author(s)
Ogasawara S, Kanai F, Obi S, Sato S, Yamaguchi T, Azemoto R, Mizumoto H, Koushima Y, Morimoto N, Hirata N, Toriyabe T, Shinozali Y, Ooka Y, Mikata R, Chiba T, Okabe S, Imazeki F, Yoshikawa M, Yokosuka O
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Journal Title
Hepatol Int
Volume: 5
Pages: 850-856
DOI
Peer Reviewed
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