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2011 Fiscal Year Final Research Report

Metabolome analysis in the gastric carcinogenesis induced by the cross-talk between Helicobacter pylori and host.

Research Project

  • PDF
Project/Area Number 21390228
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKobe University

Principal Investigator

AZUMA Takeshi  神戸大学, 医学研究科, 教授 (60221040)

Co-Investigator(Kenkyū-buntansha) YOSHINO Ken-ichi  神戸大学, バイオシグナル研究センター, 助教 (90280792)
Project Period (FY) 2009 – 2011
KeywordsH. pylori / プロテオミクス解析 / メタボロミクス解析
Research Abstract

The complete genome sequences of four Helicobacter pylori strains isolated from Japan were determined. A phylogenetic tree of concatenated well-defined core genes supported divergence of the East Asian lineage from the European lineage ancestor, and then from the Amerind lineage ancestor. Phylogenetic profiling revealed a large difference in the repertoire of outer membrane proteins. The results define H. pylori East Asian lineages and provide essential information for understanding their pathogenesis.
We investigated metabolome analysis using liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry. Lactic acid was upregulated in H. pylori infected AGS(gastric cancer cell line) cells and serum of gastric cancer patients. In contrast, malic acid was downregulated in H. pylori infected AGS cells and serum of gastric cancer patients.

  • Research Products

    (10 results)

All 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] IFN-γplays an essential role in the pathogenesis of gastric lymphoid follicles formation caused by Helicobacter suis infection2011

    • Author(s)
      Mimura T, Yoshida M, Nishiumi S, Tanaka H, Nobutani K, Takenaka M, Suleiman YB, Yamamoto K, Ota H, Takahashi S, Matsui H, Nakamura M, Miki I, Azuma T
    • Journal Title

      FEMS Immunol Med Microbiol、FEMS Immunol Med Microbiol

      Volume: 63(1) Pages: 25-34

    • Peer Reviewed
  • [Journal Article] Evolution in an oncogenic bacterial species with extreme genome plasticity : Helicobacter pylori East Asian genomes2011

    • Author(s)
      Kawai M, Furuta Y, Yahara K, Tsuru T, Oshima K, Handa N, Takahashi N, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I
    • Journal Title

      BMC Microbiol

      Volume: 11 Pages: 104

    • Peer Reviewed
  • [Journal Article] Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastric lymphoid follicles in mice through the activation of B cells and CD4 positive cells2011

    • Author(s)
      Yamamoto K, Tanaka H, Nishitani Y, Nishiumi S, Miki I, Takenaka M, Nobutani K, Mimura T, Ben Suleiman Y, Mizuno S, Kawai M, Uchiyama I, Yoshida M, Azuma T
    • Journal Title

      Microbes Infect

      Volume: 13(7) Pages: 697-708

    • Peer Reviewed
  • [Journal Article] Birth and death of genes linked to chromosomal inversion2011

    • Author(s)
      Furuta Y, Kawai M, Yahara K, Takahashi N, Handa N, Tsuru T, Oshima K, Yoshida M, Azuma T, Hattori M, Uchiyama I, Kobayashi I
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108(4) Pages: 1501-1506

    • Peer Reviewed
  • [Journal Article] Helicobacter heilmannii can induce gastric lymphoid follicles in mice via a Peyer's patch-independent pathway2010

    • Author(s)
      Nobutani K, Yoshida M, Nishiumi S, Nishitani Y, Takagawa T, Tanaka H, Yamamoto K, Mimura T, Bensuleiman Y, Ota H, Takahashi S, Matsui H, Nakamura M, Azuma T
    • Journal Title

      FEMS Immunol Med Microbiol

      Volume: 60(2) Pages: 156-164

    • Peer Reviewed
  • [Journal Article] Diversity of the cagA gene of Helicobacter pylori strains from patients with gastroduodenal diseases in the Philippines2010

    • Author(s)
      Cortes MC, Yamakawa A, Casingal CR, Fajardo LS, Juan ML, De Guzman BB, Bondoc EM ; St. Mahachai V, Yamazaki Y, Yoshida M, Kutsumi H, Natividad FF, Azuma T
    • Journal Title

      FEMS Immunol Med Microbiol

      Volume: 60(1) Pages: 90-97

    • Peer Reviewed
  • [Journal Article] The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice2010

    • Author(s)
      Tanaka H, Yoshida M, Nishiumi S, Ohnishi N, Kobayashi K, Yamamoto K, Fujita T, Hatakeyama M, Azuma T
    • Journal Title

      Arch Biochem Biophys

      Volume: 498(1) Pages: 35-42

    • Peer Reviewed
  • [Journal Article] Prescreening of a high-risk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis2010

    • Author(s)
      Mizuno S, Miki I, Ishida T, Yoshida M, Onoyama M, Azuma T, Habu Y, Inokuchi H, Ozasa K, Miki K, Watanabe Y
    • Journal Title

      Dig Dis Sci

      Volume: 55(11) Pages: 3132-3137

    • Peer Reviewed
  • [Journal Article] Infection of less virulent Helicobacter pylori strains in asymptomatic healthy individuals in Thailand as a potential contributing factor to the Asian enigma2010

    • Author(s)
      Hirai I, Sasaki T, Kimoto A, Yamamoto Y, Azuma T, Mahachai V, Hansomburana P, Lertkupinit C, Luangjaru S, Noophan P, Chanatrirattanapan R, Piyanirandr V, Sappajit T, Suthivarakom K, Sangsuk L, Wangroongsarb P
    • Journal Title

      Microbes Infect

      Volume: 12(3) Pages: 227-230

    • Peer Reviewed
  • [Patent(Industrial Property Rights)] メタボローム解析手法を用いた特定疾患の検査方法2010

    • Inventor(s)
      吉田優、西海信、東健
    • Industrial Property Rights Holder
      神戸大学
    • Industrial Property Number
      特許、特願2010-10164
    • Filing Date
      2010-04-27

URL: 

Published: 2013-07-31  

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