2011 Fiscal Year Final Research Report
Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach
| Project/Area Number |
21390231
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KATO Junji 札幌医科大学, 医学部, 教授 (20244345)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIMOTO Rishu 札幌医科大学, 医学部, 講師 (10336399)
KOBUNE Masayoshi 札幌医科大学, 医学部, 准教授 (90336389)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 糖鎖 / 内科 |
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| Research Abstract |
Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required. We developed X-bound nanoparticles as vehicles for delivery of anticancer drugs specifically to cancer cells. X-bound liposomes containing Cy5. 5 or Cisplatin were effectively delivered into CA19-9 expressing pancreatic cancer cells. Intravenously injected X-bound liposomes carrying Cisplatin were successfully delivered to pancreatic cancer cells, mediating efficient tumor growth inhibition as well as prolonging survival in mouse xenograft models. This modality represents a new strategy for pancreatic cancer cell-targeting therapy.
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