Identification of novel cell lineages contributing to cardiovascular development and clarification of mechanisms underlying their fate determination

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390238
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: KURIHARA Hiroki 東京大学, 大学院・医学系研究科, 教授 (20221947)
• Co-Investigator(Renkei-kenkyūsha): KURIHARA Yukiko 東京大学, 大学院・医学系研究科, 講師 (80345040) ; NISHIYAMA Koichi 東京大学, 大学院・医学系研究科, 助教 (80398221) ; UCHIJIMA Yasunobu 東京大学, 大学院・医学系研究科, 助手 (90272426) ; TOMITA Sachiko 東京女子医科大学, 医学部, 助教 (40231451)
• Project Period (FY): 2009 – 2011
• Keywords: 分子心臓病態学 / 心筋細胞 / 心臓発生 / 細胞分化 / 血管内皮細胞 / 血管新生

Research Abstract

Early endothelin receptor type A expression defines a subdomain of the first heart field contributing to chamber formation, in which endothelin signaling is involved by stimulating ERK phosphorylation and Tbx5 expression. In angiogenesis, complex cell behavior and tip cell overtaking were revealed to contribute to branching morphogenesis by a time-lapse imaging and computer-assisted analysis.

Research Products

• [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development (2012)
  • Author(s): Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Pages: 291-298
  • DOI: DOI:10.1161/ATVBAHA.111.234559
  • Peer Reviewed
• [Journal Article] Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement (2011)
  • Author(s): Arima S, Nishiyama K, Ko T, Arima Y, Hakozaki Y, Sugihara K, Koseki H, Uchijima Y, Kurihara Y, Kurihara H.
  • Journal Title: Development Volume: 138 Pages: 4763-4776
  • DOI: DOI:10.1242/dev.068023
  • Peer Reviewed
• [Journal Article] Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney (2011)
  • Author(s): Kitazawa T, Sato T, Nishiyama K, Asai R, Arima Y, Uchijima Y, Kurihara Y, Kurihara H.
  • Journal Title: Gene Expr. Patterns Volume: 11 Pages: 371-377
  • DOI: DOI:10.1016/j.gep.2011.04.001
  • Peer Reviewed
• [Journal Article] Calpain 6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1 (2011)
  • Author(s): Tonami K, Kurihara Y, Arima S, Nishiyama K, Uchijima Y, Asano T, Sorimachi H, Kurihara H.
  • Journal Title: J. Cell Sci Volume: 124 Pages: 1214-1223
  • DOI: DOI:10.1242/dev.068023
  • Peer Reviewed
• [Journal Article] Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest (2010)
  • Author(s): Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H.
  • Journal Title: J. Clin. Invest Volume: 120 Pages: 2817-2828
  • DOI: DOI:10.1172/JCI42020
  • Peer Reviewed
• [Journal Article] Endothelin receptor type-A expression defines a distinct cardiac subdomain within the heart field, with a later implication of this signaling pathway in chamber myocardium formation (2010)
  • Author(s): Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H.
  • Journal Title: Development Volume: 137 Pages: 3823-3833
  • DOI: DOI:10.1242/dev.054015
  • Peer Reviewed
• [Journal Article] Establishment of mice expressing EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst (2010)
  • Author(s): Fujimoto C, Ozeki H, Uchijima Y, Suzukawa K, Mitani A, Fukuhara S, Nishiyama K, Kurihara Y, Kondo K, Aburatani H, Kaga K, Yamasoba T, Kurihara H.
  • Journal Title: J. Comp. Neurol Volume: 18 Pages: 4702-4722
  • DOI: DOI:10.1002/cne.22468
  • Peer Reviewed
• [Journal Article] Jaw muscularization requires Dlx expression by cranial neural crest cells (2010)
  • Author(s): Heude E, Bouhali K, Kurihara Y, Kurihara H, Couly G, Janvier P, Levi G.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107 Pages: 11441-11446
  • DOI: DOI:10.1073/pnas.1001582107
  • Peer Reviewed
• [Journal Article] Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw (2010)
  • Author(s): Vieux-Rochas M, Mantero S, Heude E, Barbieri O, Astigiano S, Couly G, Kurihara H, Levi G, Merlo GR.
  • Journal Title: Genesis Volume: 48 Pages: 262-273
  • DOI: DOI:10.1002/dvg.20625
  • Peer Reviewed
• [Journal Article] Evolving maps in craniofacial development (2010)
  • Author(s): Gitton Y, Heude E, Vieux-Rochas M, Benouaiche L, Fontaine A, Sato T, Kurihara Y, Kurihara H, Couly G, Levi G.
  • Journal Title: Semin. Cell. Dev. Biol Volume: 21 Pages: 301-308
  • DOI: DOI:10.1016/j.semcdb.2010.01.008
  • Peer Reviewed
• [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity (2010)
  • Author(s): Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T.
  • Journal Title: J. Biol. Chem Volume: 285 Pages: 33018-33027
  • DOI: DOI:10.1074/jbc.M110.137836
  • Peer Reviewed
• [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy (2010)
  • Author(s): Cui X, Kushiyama A, Yoneda M, Nakatsu Y, Guo Y, Zhang J, Ono H, Kanna M, Sakoda H, Ono H, Kikuchi T, Fujishiro M, Shiomi M, Kamata H, Kurihara H, Kikuchi M, Kawazu S, Nishimura F, Asano T.
  • Journal Title: Diabetes Res. Clin. Pract Volume: 87 Pages: 57-63
  • DOI: DOI:10.1016/j.diabres.2009.10.011
  • Peer Reviewed
• [Journal Article] Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis (2010)
  • Author(s): Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M.
  • Journal Title: Blood Volume: 115 Pages: 4138-4147
  • DOI: DOI:0.1182/blood-2009-05-223057
  • Peer Reviewed
• [Journal Article] Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice (2010)
  • Author(s): Mishima T, Ito Y, Hosono K, Tamura Y, Uchida Y, Hirata M, Suzuki T, Amano H, Kato S, Kurihara Y, Kurihara H, Hayashi I, Watanabe M, Majima M.
  • Journal Title: Am. J. Physiol. Heart Circ. Physiol Volume: 300 Pages: 431-439
  • DOI: DOI:10.1152/ajpheart.00466.2010
  • Peer Reviewed
• [Journal Article] Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice (2009)
  • Author(s): Mitani A, Nagase T, Fukuchi K, Aburatani H, Makita R, Kurihara H.
  • Journal Title: Am. J. Respi. r Crit. Care. Med Volume: 180 Pages: 326-338
  • DOI: DOI:10.1164/rccm.200812-1827OC
  • Peer Reviewed
• [Journal Article] The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass (2009)
  • Author(s): Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson R O, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki E M, Nojima H, Rossant J, Nakao K, Niwa H, Sasaki H.
  • Journal Title: Dev. Cell Volume: 16 Pages: 398-410
  • DOI: DOI:10.1016/j.devcel.2009.02.003
  • Peer Reviewed
• [Journal Article] A high-speed congenic strategy using first-wave male germ cells (2009)
  • Author(s): Ogonuki N, Inoue K, Hirose M, Miura I, Mochida K, Sato T, Mise N, Mekada K, Yoshiki A, Abe K, Kurihara H, Wakana S, Ogura A.
  • Journal Title: PLoS ONE Volume: 4 Pages: e4943
  • DOI: DOI:10.1371/journal.pone.0004943
  • Peer Reviewed
• [Presentation] Hox gene function and possible crosstalk with Dlx genes in craniofacial morphogenesis (2012)
  • Author(s): Taro Kitazawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: Four Points by Sheraton Los Angeles(USA)
  • Year and Date: 20120319-20
• [Presentation] Involvement of non-coding RNA : Evf2 in the Endothelin signaling in branchial arch development (2012)
  • Author(s): Yukiko Kurihara
  • Organizer: Keystone Symposia Canference Non-Coding RNAs
  • Place of Presentation: Snowbird Cliff lodge(USA)
  • Year and Date: 2012-04-02
• [Presentation] Protective role of Sirt3 against p53-dependent developmental arrest induced by oxidative stress in preimplantation embryos (2012)
  • Author(s): Yumiko Kawamura
  • Organizer: Keystone Symposia "Sirtuins in metabolism, aging and disease"
  • Place of Presentation: Granlibakken Resort, Tahoe City, California(USA)
  • Year and Date: 2012-02-13
• [Presentation] Collective endothelial cell movement in angiogenic morphogenesis (2011)
  • Author(s): Koichi Nishiyama
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando Convention Center(USA)
  • Year and Date: 2011-11-15
• [Presentation] Coronary artery anomalies in Endothelin-1 and Endothelin A receptor knockout mice (2011)
  • Author(s): Yuichiro Arima
  • Organizer: American Heart Association Scientific Session
  • Place of Presentation: Orlando Convention Center(USA)
  • Year and Date: 2011-11-15
• [Presentation] The first heart field subdomain defined by endothelin receptor type-A expression contributes to conduction system development (2011)
  • Author(s): Rieko Asai
  • Organizer: ESC Working Group on Developmental Anatomy and Pathology
  • Place of Presentation: Liblice Casstle(Czech)
  • Year and Date: 2011-09-24
• [Presentation] Endothelin receptor type-A expression defines a distinct subdomain within the heart field and contributes to chamber myocardium (2011)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Development Conference 2011
  • Place of Presentation: Hilton Cincinnati(USA)
  • Year and Date: 2011-05-06
• [Presentation] Endothelin-1/Endothelin type-A receptor signaling regulates pharyngeal arch artery development through Dlx5/6-independent pathway (2011)
  • Author(s): Ki-Sung Kim
  • Organizer: 2011 Pediatric Academic Societies and Asian Society for Pediatric Research joint meeting
  • Place of Presentation: Denver Convention Center(USA)
  • Year and Date: 2011-05-01
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium (2010)
  • Author(s): Rieko Asai
  • Organizer: Weinstein 2010 cardiovascular development conference
  • Place of Presentation: Royal Tropical Institute, AMSTERDAM(Netherlands)
  • Year and Date: 2010-05-21
• [Presentation] Non-cording RNA regulation of endothelin signaling in branchial arch development (2010)
  • Author(s): Yukiko Kurihara
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: I Ciocco Hotel & Resort, Lucca(Italy)
  • Year and Date: 2010-04-13
• [Presentation] Subtype-specific domain functions of endothelin receptors in craniofacial development (2010)
  • Author(s): Kou Fujisawa
  • Organizer: Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration
  • Place of Presentation: I Ciocco Hotel & Resort, Lucca(Italy)
  • Year and Date: 2010-04-12
• [Presentation] Id1 regulates angiogenesis by determining the specification and the timing of Notch signaling (2009)
  • Author(s): Koichi Nishiyama
  • Organizer: American Heart Association, scientific session
  • Place of Presentation: Orange County Convention Center, Orlando(USA)
  • Year and Date: 20091108-12
• [Presentation] Endothelin type-A receptor expression defines a distinct subdomain within the crescent-forming heart field contributing to chamber myocardium (2009)
  • Author(s): Rieko Asai
  • Organizer: Weinstein Cardiovascular Developmental Conference
  • Place of Presentation: Hyatt Embarcadero Hotel, San Francisco(USA)
  • Year and Date: 20090507-09
• [Remarks]
  • URL: http://bio.m.u-tokyo.ac.jp/