Role of intracellular degradation systems in genesis of heart failure

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390240
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: OTSU Kinya 大阪大学, 医学系研究科, 准教授 (20294051)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Osamu 大阪大学, 大学院・医学系研究科, 助教 (90467580) ; HIKOSO Shungo 大阪大学, 大学院・医学系研究科, 助教 (30423164)
• Project Period (FY): 2009 – 2011
• Keywords: 細胞内分解系 / 心不全 / 細胞死

Research Abstract

In this study, we examined the role of degradation systems in the genesis of heart failure. Our results indicate that calpain plays a cardioprotective role and autophagy is important to maintain cardiac function during aging. Furthermore, DNase II regulates inflammatory responses in the heart by degrading mitochondrial DNA.

Research Products

• [Journal Article] Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure (2012)
  • Author(s): 岡崇史、彦惣俊吾、山口修、種池学、武田理宏、玉井敬人、大藪丈太、村川智一、中山博之、西田和彦、審良静男、山本章次、小室一成、大津欣也
  • Journal Title: Nature Volume: (in press)
  • Peer Reviewed
• [Journal Article] Calpain protects the heart from hemodynamic stress (2011)
  • Author(s): 種池学、溝手勇、森田孝、渡部徹也、彦惣俊吾、山口修、武田理宏、岡崇史、玉井敬人、大藪丈太、村川智一、中山博之、西田和彦、竹田潤二、望月直樹、小室一成、大津欣也
  • Journal Title: The Journal of Biological Chemistory Volume: 286 Pages: 32170-7
  • Peer Reviewed
• [Journal Article] Inhibition of autophagy in the heart induces age-related cardiomyopathy (2010)
  • Author(s): 種池学、山口修、中井敦子、彦惣俊吾、武田理宏、溝手勇、岡崇史、玉井敬人、大藪丈太、村川智一、西田和彦、清水孝彦、堀正二、小室一成、白澤卓司、水島昇、大津欣也
  • Journal Title: Autophagy Volume: 6 Pages: 1-7
  • Peer Reviewed
• [Presentation] Molecular link between cell death and sterile inflammation (2012)
  • Author(s): 大津欣也
  • Organizer: ヨーロッパ心不全学会冬季研究学会
  • Place of Presentation: スイス
  • Year and Date: 2012-01-19
• [Presentation] Inflammation and autophagy (2011)
  • Author(s): 大津欣也
  • Organizer: 基礎心臓病学カンファレンス、ラスベガス
  • Place of Presentation: アメリカ合衆国
  • Year and Date: 2011-07-19
• [Presentation] Lysosomal DNaseII Digests Mitochondrial DNA Through Lysosome/ Autophagy System to Maintain Cardiac Function in Pressured-Overloaded Hearts (2010)
  • Author(s): 岡崇史
  • Organizer: 米国心臓学会
  • Place of Presentation: シカゴ、アメリカ合衆国
  • Year and Date: 2010-11-10
• [Presentation] 血行動態負荷並びに老化における心筋細胞オートファジーの役割 (2010)
  • Author(s): 山口修
  • Organizer: 第14回日本心不全学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-10
• [Presentation] Constitutive Autophagy is Necessary for Maintenance of Cardiac Structure and Function in Aged mouse Hearts (2010)
  • Author(s): 種池学
  • Organizer: 第10回国際心臓研究学会世界大会
  • Place of Presentation: 京都
  • Year and Date: 2010-05-10
• [Presentation] The in vivo Role of IKKb/ NF-kB Signaling Pathway in the Heart (2009)
  • Author(s): 彦惣俊吾
  • Organizer: 第26回国際心臓研究学会日本部会
  • Place of Presentation: 札幌
  • Year and Date: 2009-12-01
• [Presentation] MAPK Signaling and Regulation of Cardiac Hypertrophy (2009)
  • Author(s): 大津欣也
  • Organizer: 基礎心臓病学カンファレンス、ラスベガス
  • Place of Presentation: アメリカ合衆国
  • Year and Date: 2009-07-20
• [Presentation] Autophagy and apoptosis in heart disease (2009)
  • Author(s): 大津欣也
  • Organizer: ヨーロッパ心不全学会
  • Place of Presentation: ニース、フランス
  • Year and Date: 2009-05-20