2011 Fiscal Year Final Research Report
Roles of Angiotensin II Receptor-Associated Protein in Vascular Senescence
| Project/Area Number |
21390242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IWAI Masaru 愛媛大学, 大学院医学系研究科, 准教授 (00184854)
MOGI Masaki 愛媛大学, 大学院医学系研究科, 講師 (20363236)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 血管老化 / アンジオテンシン / 受容体 |
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| Research Abstract |
Angiotensin II mediates various effects through complex signaling pathways on binding to its G-protein-coupled receptors(GPCRs), the angiotesin II type 1(AT1) receptor and type 2(AT2) receptor. These receptors are regulated by GPCR-interacting proteins such as AT1 receptor-associated protein(ATRAP), and AT2 receptor-interacting protein(ATIP), which we have cloned. In this study, we demonstrated that ATRAP and ATIP negatively regulated vascular smooth muscle cell(VSMC) senescence in concert with the cross-talk of each angiotensin II receptor subtype.
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