2012 Fiscal Year Final Research Report
Redox-mediated regulation of endothelial function
| Project/Area Number |
21390243
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
AGO Tetsuro 九州大学, 大学病院, 助教 (30514202)
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| Research Collaborator |
SADOSHIMA Junichi UMDNJ-New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Professor
KURODA Junya 九州大学, 大学病院, 助教 (70614858)
ARIMURA Koichi 九州大学, 大学院・医学研究院, 大学院生
NISHIMURA Ataru 九州大学, 大学院・医学研究院, 大学院生
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| Project Period (FY) |
2009 – 2012
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| Keywords | 酸化ストレス / レドックス / Nox4 / NADPH oxidase / 内皮細胞 / 脳虚血 / 血管新生 / ミトコンドリア |
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| Research Abstract |
Reactive oxygen species (ROS) play an important role in the development and progression of cardiovascular diseases. In the present study, we focused on the ROS-producing enzyme Nox4 expressed in endothelial cells. While the expression of Nox4 was suppressed under normal conditions, it was highly induced in micro-vessels in ischemic tissues, reinforced hypoxic responses, and increased the production of angiogenic and inflammatory molecules. The physiological role of Nox4 may be angiogenesis; however, the angiogenic responses induced by rapid induction of Nox4 may rather worsen the disease state under particular conditions, such as brain ischemia.
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