2011 Fiscal Year Final Research Report
Development of Chronotherapy for Cardiovascular Diseases
| Project/Area Number |
21390244
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
MAEMURA Koji 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90282649)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Satoshi 長崎大学, 大学院・医歯薬学総合研究科, 講師 (10336159)
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| Co-Investigator(Renkei-kenkyūsha) |
MORITA Hiroyuki 東京大学, 大学院・医学系研究科, 特任准教授 (60323573)
SADANAGA Tsuneaki 熊本市立植木病院
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| Project Period (FY) |
2009 – 2011
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| Keywords | 循環器疾患 / 時間薬理学 / メラトニン |
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| Research Abstract |
We investigated the effect of administration time of RAS blockades on renal function associated with congestive heart failure. The patients who took RAS blockades in the evening showed less urinary albumin excretion compared with those in the morning. Melatonin, which exhibits clear circadian rhythm, suppressed ROS generation in endothelial cells and improved endothelial function. The results define the potential clinical applicability of melatonin to the prevention from cardiovascular diseases, especially in patients who are under disturbed circadian rhythm.
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