2011 Fiscal Year Final Research Report
Understanding the pathogenesis of severe airway diseases by large cohort studies
| Project/Area Number |
21390253
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONNO Satoshi 北海道大学, 大学院・医学研究科, 講師 (20399835)
NASUHARA Yasuyuki 北海道大学, 北海道大学病院, 准教授 (30322811)
MAKITA Hironi 北海道大学, 医学研究科, 客員研究員 (70533537)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 難治性喘息 / COPD / コホート研究 |
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| Research Abstract |
The rate of annual change in post-bronchodilator FEV1 is highly variable over a period of 5 years among patients with COPD who receive appropriate therapy. Emphysema severity, which varies substantially even for the same spirometric stage, is independently associated with a rapid annual decline in FEV1. The presence of sustainers, who can maintain pulmonary function, warrants specific attention together with rapid decliners in clinical practice.
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