2011 Fiscal Year Final Research Report
Study on the pathogenesis of asthma and COPD-genetic heterogeneity and pharmacogenetics-
| Project/Area Number |
21390254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Tohru 筑波大学, 医学医療系, 准教授 (50282356)
NOGUCHI Emiko 筑波大学, 医学医療系, 准教授 (40344882)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMARI Mayumi 独立行政法人理化学研究所, ゲノム医科学研究センター, チームリーダー (00217184)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 喘息 / COPD / 感受性遺伝子 / テーラーメイド / 呼吸機能 |
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| Research Abstract |
Severe asthma is a heterogeneous condition. In older patients, asthma-COPD overlap syndrome becomes more prevalent as patients become less atopic and their airflow obstruction become less reversible. Airflow obstruction (FEV1) and annual FEV1 decline were associated with TSLP and Nrf2, respectively, in healthy adults without evident pulmonary diseases. Both genes, which function as sensors of outside world, are potential markers of an increased susceptibility to obstructive lung disease such as asthma and COPD. In a study of pharmacogenetics, asthma patients had variable responses to a combination treatment of inhaled corticosteroid with salmeterol or with montelukast, but ADRB2 genotype had no influence on these variable responses.
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[Journal Article] Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis : case-control studies2011
Author(s)
Hirota T, Saeki H, Tomita K, Hizawa N, Sakamoto T, Masuko H, Sasaki T, Ebihara T, Amagai M, Esaki H, Takeuchi S, Furue M, Noguchi E, Kamatani N, Nakamura Y, Kubo M, Tamari M
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Journal Title
PLoS One
Volume: 6(11)
Pages: e26987
Peer Reviewed
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[Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma2011
Author(s)
Harada M, Hirota T, Noguchi E, Sakamoto T, Hizawa N, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M
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Journal Title
Am J Respir Cell Mol Biol
Volume: 44(6)
Pages: 787-93
Peer Reviewed
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[Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations2011
Author(s)
Noguchi E, Sakamoto H, Hirota T, Ochiai K, Kohno Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Yamashita F, Asada T, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K
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Journal Title
PLoS Genet
Volume: 7(7)
Pages: e1002170
Peer Reviewed
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[Journal Article] Blockade of cysteinyl leukotriene-1 receptors suppresses airway remodelling in mice overexpressing GATA-32011
Author(s)
Kiwamoto T, Ishii Y, Morishima Y, Yoh K, Kikuchi N, Haraguchi N, Masuko H, Kawaguchi M, Nomura A, Sakamoto T, Takahashi S, Hizawa N
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Journal Title
Clin Exp Allergy
Volume: 41(1)
Pages: 116-28
Peer Reviewed
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[Journal Article] Japanese-Specific Filaggrin Gene Mutations in Japanese Patients Suffering from Atopic Eczema and Asthma2010
Author(s)
Osawa R, Konno S, Akiyama M, Nemoto-Hasebe I, Nomura T, Nomura Y, AbeR, Sandilands A, McLean WH, Hizawa N, Nishimura M, Shimizu H
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Journal Title
J Invest Dermatol
Volume: 130(12)
Pages: 2834-6
Peer Reviewed
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[Journal Article] Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis2010
Author(s)
Hattori T, Konno S, Takahashi A, Isada A, Shimizu K, Shimizu K, Taniguchi N, Gao P, Yamaguchi E, Hizawa N, Huang SK, Nishimura M
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Journal Title
BMC Med Genet
Volume: 11
Pages: 151
Peer Reviewed
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[Journal Article] Osteopontin is involved in migration of eosinophils in asthma2009
Author(s)
Takahashi A, Kurokawa M, Konno S, Ito K, Kon S, Ashino S, Nishimura T, Uede T, Hizawa N, Huang SK, Nishimura M
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Journal Title
Clin Exp Allergy
Volume: 39(8)
Pages: 1152-9
Peer Reviewed
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[Presentation] Decrease dpre-bronchodilator FEV1 as a potential risk factor for COPD2010
Author(s)
Masuko H, Sakamoto T, Ano S, Fujita J, Yageta Y, Yamadori T, Kikuchi N, Haraguchi N, Homma S, Kawaguchi M, Morishima Y, Ishii Y, Iijima H, Naito T, Hizawa N
Organizer
ATS international conference
Place of Presentation
New Orleans
Year and Date
20100514-19
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[Presentation] Genetic ablation of Nrf2exacerbates influenza virus-induced lung injury after cigarette smoke exposure in mice2010
Author(s)
Yageta Y, Kikuchi N, Haraguchi N, Masuko H, Ano S, Yamadori T, Morishima Y, Ishii Y, Kawaguchi A, Takeuchi K, Nagata K, Hizawa N
Organizer
ATS international conference
Place of Presentation
New Orleans
Year and Date
20100514-19
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