2011 Fiscal Year Final Research Report
Mechanisms of cardiovascular-renal connection on life-style diseases
| Project/Area Number |
21390259
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
ITO Sadayoshi 東北大学, 大学院・医学系研究科, 教授 (40271613)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Takefumi 東北大学, 医学系研究科, 准教授 (40375001)
ABE Michiaki 東北大学, 病院, 助教 (40400246)
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| Project Period (FY) |
2009 – 2011
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| Keywords | メチルグリオキサール / 腎血行動態 / 酸化ストレス / インスリン抵抗性 / 高血圧 |
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| Research Abstract |
Present study determined the mechanisms of cardiovascular renal injury in CKD and the role of MG. 1%MG in drinking water was administered to Dahl salt sensitive rats exhibited increase in blood pressure associated with cardiovascular-renal injury. Cerebrovascular renal injury was observed in high salt fed stroke-prone spontaneously hypertensive rats, which was associated with blood pressure and oxidative stress. Glucose induced mitochondrial oxidative stress was observed in the tubules of juxtamedullary nephron, which was inhibited in glyoxalase 1 trangenic rats, indicating that carbonyl stress is responsible for glucose mediated renal injury
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