2011 Fiscal Year Final Research Report
Roles of a novel kidney-specific prostaglandin(PG) transporter in local PG clearance in renal cortex and its pathological relevance
| Project/Area Number |
21390264
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAMORI Shushi 大阪大学, 大学院・医学系研究科, 助教 (90467572)
OHGAKI Ryuichi 大阪大学, 大学院・医学系研究科, 助教 (20467525)
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| Project Period (FY) |
2009 – 2011
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| Keywords | トランスポーター / プロスタグランジン / 近位尿細管 / 傍糸球体装置 / レニン |
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| Research Abstract |
In renal cortex, prostaglandin E_2(PGE_2) is released from the macula densa of distal tubules and functions as an autacoid responsible for the regulation of tubuloglomerular feedback and renin release from the juxtaglomerular apparatus. However, the molecular mechanisms through which released PGE_2 is removed and PGE_2 signal is turned off have not been understood. By using knockout mice in which the gene for the novel prostaglandin-specific transporter OAT-PG is disrupted, this study has addressed the questions. The results in this study indicate that OAT-PG is the transporter responsible for the local prostaglandin clearance in renal cortex.
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