2011 Fiscal Year Final Research Report
Artificial control of blood-nerve barrier : an approach toward the novel therapeutics of intractable human peripheral nervous system disorders
| Project/Area Number |
21390268
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KANDA Takashi 山口大学, 大学院・医学系研究科, 教授 (40204797)
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| Co-Investigator(Renkei-kenkyūsha) |
TERASAKI Tetsuya 東北大学, 薬学部薬学研究科, 教授 (60155463)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 血液神経関門 / トランスポーター / 血管内皮細胞 / 血管周細胞 / 末梢神経障害 |
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| Research Abstract |
We analyzed the molecular mechanisms of blood-nerve barrier(BNB) malfunction in various neuropathies, using immortal cell lines of human BNB origin recently established in our laboratory. Sera from some group of patients with inflammatory neuropathies can destroy BNB. Advanced glycation end-products(AGE), the late products of non-enzymatic glycation increased in diabetic condition, are shown to impair BNB via upregulation of VEGF and TGF. Various transporters in the membrane of barrier-forming endothelial cells can be a appropriate target toward the novel therapeutics of intractable human peripheral nervous system disorders.
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