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2011 Fiscal Year Final Research Report

Generation of pathological models for Parkinson's disease

Research Project

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Project/Area Number 21390272
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionJuntendo University

Principal Investigator

HATTORI Nobutaka  順天堂大学, 医学部, 教授 (80218510)

Co-Investigator(Kenkyū-buntansha) SATO Shigeto  順天堂大学, 医学部, 准教授 (00445537)
SHIMO Yasushi  順天堂大学, 医学部, 准教授 (70286714)
FUNAYAMA Funayama  順天堂大学, 医学研究科, 准教授 (70468578)
Project Period (FY) 2009 – 2011
Keywordsパーキンソン病 / モデルマウス / ミトコンドリア / ミトファジー / Parkin / PINK1 / NDUFV2 / MPTP
Research Abstract

To understand the pathology of Parkinson's disease, mouse models that replicate Parkinson's disease symptoms are indispensable. However, currently none of the models are able to meet the pathological demands. The present study will attempt to create a novel NADH dehydrogenase(ubiquinone) flavoprotein 2, 24kDa(NDUFV2) knockout mouse and familial Parkinson's disease causative gene PINK1 knockout mouse that presents mitochondrial dysfunction, based on the cause of Parkinson's disease, which will be useful for future studies.

  • Research Products

    (41 results)

All 2011 2010 2009

All Journal Article (20 results) Presentation (20 results) Book (1 results)

  • [Journal Article] Methotrexate leukoencephalopathy mimics acute progressive stroke2011

    • Author(s)
      Tanaka R, Sasaki-Ikesawa K, Shimura H, Nishioka K, Hattori N, Tanaka S
    • Journal Title

      J Neurol

      Volume: 258(11) Pages: 2083

  • [Journal Article] Genetic Epidemiology of Parkinson's Disease Consortium. Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease2011

    • Author(s)
      Sharma M, Maraganore DM, Ioannidis JP, Riess O, Aasly JO, Annesi G, Abahuni N, Bentivoglio AR, Brice A, Van Broeckhoven C, Chartier-Harlin MC, Destee A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Gispert S, Hattori N, Jasinska-Myga B, Klein C
    • Journal Title

      Neurobiol Aging

      Volume: 32(11) Pages: e1-5

  • [Journal Article] Art and Parkinson's disease : a dramatic change in an artist's style as an initial symptom2011

    • Author(s)
      Shimura H, Tanaka R, Urabe T, Tanaka S, Hattori N
    • Journal Title

      J Neurol

      Volume: (In Press)

  • [Journal Article] Genetic Epidemiology Of Parkinson's Disease(GEO-PD) Consortium. Association of LRRK2 exonic variants with susceptibility to Parkinson's disease : a case-control study2011

    • Author(s)
      Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Ferraris A, Fiske B, Gibson JM,Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, van de Loo S, Vassilatis DK, Vilarino-Guell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Farrer MJ
    • Journal Title

      Lancet Neurol

      Volume: 10(10) Pages: 898-908

  • [Journal Article] Genetic mutations and functions of PINK12011

    • Author(s)
      Kawajiri S, Saiki S, Sato S, Hattori N
    • Journal Title

      Trends Pharmacol Sci

      Volume: 32(10) Pages: 573

  • [Journal Article] Demographic, Clinical, and Radiologic Predictors of Neurologic Deterioration in Patients with Acute Ischemic Stroke2011

    • Author(s)
      Miyamoto N, Tanaka Y, Ueno Y, Kawamura M, Shimada Y, Tanaka R, Hattori N, Urabe T
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: (In Press)

  • [Journal Article] Convulsive movements in bilateral paramedian thalamic and midbrain infarction2011

    • Author(s)
      Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y
    • Journal Title

      Case Rep Neurol

      Volume: 3(3) Pages: 289

  • [Journal Article] Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease2011

    • Author(s)
      Seki N, Takahashi Y, Tomiyama H, Rogaeva E, Murayama S, Mizuno Y, Hattori N, Marras C, Lang AE, George-Hyslop PS, Goto J, Tsuji S
    • Journal Title

      J Hum Genet

      Volume: 56(9) Pages: 671

  • [Journal Article] DJ-1 associates with synaptic membranes2011

    • Author(s)
      Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
    • Journal Title

      Neurobiol Dis

      Volume: 43(3) Pages: 651

  • [Journal Article] Improvements in both psychosis and motor signs in Parkinson's disease, and changes in regional cerebral blood flow after electroconvulsive therapy2011

    • Author(s)
      Usui C, Hatta K, Doi N, Kubo S, Kamigaichi R, Nakanishi A, Nakamura H, Hattori N, Arai H
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35(7) Pages: 1704-8

  • [Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia2011

    • Author(s)
      Teramoto S, Miyamoto N, Yatomi K, Tanaka Y, Oishi H, Arai H, Hattori N, Urabe T
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 31(8) Pages: 1696

  • [Journal Article] Parkin-mediated protection of dopaminergic neurons in a chronic MPTP-minipump mouse model of Parkinson disease2011

    • Author(s)
      Yasuda T, Hayakawa H, Nihira T, Ren YR, Nakata Y, Nagai M, Hattori N, Miyake K, Takada M, Shimada T, Mizuno Y, Mochizuki H
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 70(8) Pages: 686-97

  • [Journal Article] The effect of Ndrg2 expression on astroglial activation2011

    • Author(s)
      Takeichi T, Takarada-Iemata M, Hashida K, Sudo H, Okuda T, Kokame K, Hatano T, Takanashi M, Funabe S, Hattori N, Kitamura O, Kitao Y, Hori O
    • Journal Title

      Neurochem Int

      Volume: 59(1)

  • [Journal Article] Analysis of PLA2G6 in patients with frontotemporal type of dementia2011

    • Author(s)
      Tomiyama H, Yoshino H, Hattori N
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 17(6) Pages: 493-4

  • [Journal Article] Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice2011

    • Author(s)
      Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N
    • Journal Title

      Neurobiol Dis

      Volume: 42(3) Pages: 404-14

  • [Journal Article] PLA2G6 variant in Parkinson's disease2011

    • Author(s)
      Tomiyama H, Yoshino H, Ogaki K, Li L, Yamashita C, Li Y, Funayama M, Sasaki R, Kokubo Y, Kuzuhara S, Hattori N
    • Journal Title

      J Hum Genet

      Volume: 56(5) Pages: 401-3

  • [Journal Article] Posterior hypoperfusion in Parkinson's disease with and without dementia measured with arterial spin labeling MRI2011

    • Author(s)
      Kamagata K, Motoi Y, Hori M, Suzuki M, Nakanishi A, Shimoji K, Kyougoku S, Kuwatsuru R, Sasai K, Abe O, Mizuno Y, Aoki S, Hattori N
    • Journal Title

      J Magn Reson Imaging

      Volume: 33(4) Pages: 803-7

  • [Journal Article] Phenotype of the 202 adenine deletion in the parkin gene : 40 years of follow-up2011

    • Author(s)
      Hassin-Baer S, Hattori N, Cohen OS, Massarwa M, Israeli-Korn SD, Inzelberg R
    • Journal Title

      Mov Disord

      Volume: 26(4) Pages: 719-22

  • [Journal Article] Genetic Epidemiology of Parkinson's disease consortium. A large-scale genetic association study to evaluate the contribution of Omi/HtrA2(PARK13) to Parkinson's disease2011

    • Author(s)
      Kruger R, Sharma M, Riess O, Gasser T, Van Broeckhoven C, Theuns J, Aasly J, Annesi G, Bentivoglio AR, Brice A, Djarmati A, Elbaz A, Farrer M, Ferrarese C, Gibson JM, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Klein C, Lambert JC, Lesage S, Lin JJ, Lynch T, Mellick GD, de Nigris F, Opala G, Prigione A, Quattrone A, Ross OA, Satake W, Silburn PA, Tan EK, Toda T, Tomiyama H, Wirdefeldt K, Wszolek Z, Xiromerisiou G, Maraganore DM
    • Journal Title

      Neurobiol Aging

      Volume: 32(3) Pages: e9-18

  • [Journal Article] Acute effects of bilateral subthalamic stimulation on decision-making in Parkinson's disease2011

    • Author(s)
      Oyama G, Shimo Y, Natori S, Nakajima M, Ishii H, Arai H, Hattori N
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 17(3) Pages: 189-93

  • [Presentation] 遺伝性パーキンソン病の共通分子基盤の解明2011

    • Author(s)
      服部信孝
    • Organizer
      仙台神経変性疾患検討会
    • Place of Presentation
      仙台
    • Year and Date
      2011-12-08
  • [Presentation] パーキンソン病2011

    • Author(s)
      服部信孝
    • Organizer
      第38回ヒューマンサイエンス総合研究セミナー「難病創薬のビジネスモデルと可能性-神経変性疾患を中心-」に係る講師の依頼について,平成23年度厚生労働科学研究費補助金政策創薬総合研究事業,立がん研究センター内
    • Place of Presentation
      国際研究交流会館(東京)
    • Year and Date
      2011-10-03
  • [Presentation] Neurodegeneration. Prevention-Regeneration. Academic Session : Preventive and Translational Medicine. Perspectives for 21 Centuries2011

    • Author(s)
      服部信孝
    • Organizer
      Joint Japanese. German Symposium
    • Place of Presentation
      Juntendo University
    • Year and Date
      2011-09-27
  • [Presentation] 加齢と神経変性疾,ベーシックサイエンス企画シンポジウム2,「加齢性疾患とエピジェネティクス」2011

    • Author(s)
      服部信孝
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      日国立京都国会館
    • Year and Date
      2011-05-27
  • [Presentation] パーキンソン病治療における脳深部刺激療法の役割パーキンソン病のMoto/Non-Motorに対する電気刺激治療の試み2011

    • Author(s)
      下泰司
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-19
  • [Presentation] 神経変性をどう考えるか?病態理解に至る最近の進歩.シンポジウム14「若年性パーキンソン病の病態解明:インスリン開口機構からその病因に迫る」2011

    • Author(s)
      服部信孝
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-19
  • [Presentation] 家族性パーキンソン病とミトコンドリア品質管理の異常2011

    • Author(s)
      佐藤栄人
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-05-18
  • [Presentation] The Pathogenesis of Parkinson's Disease : A Hint of Insights from Monogenic Form of Parkinson's Disease2011

    • Author(s)
      服部信孝
    • Organizer
      Quadricentennial Neuroscience Summit 2011
    • Place of Presentation
      University of Santo Tomas
    • Year and Date
      2011-01-02
  • [Presentation] Symposium IV : MITOCHONDRIAL DYSFUNCTION2010

    • Author(s)
      服部信孝
    • Organizer
      Functional Genomics of Parkinson's Disease
    • Place of Presentation
      Tubingen
    • Year and Date
      2010-11-19
  • [Presentation] アジア初のα-synuclein遺伝子三重複変異2010

    • Author(s)
      舩山学、関根威、加賀谷肇、李元哲、吉野浩代、富山弘幸、服部信孝
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-29
  • [Presentation] New Strategies for Neurotherapecutic Intervention of Neurodegenerative Disorders : A Hint From Monogenic of Familial Parkinson's Disease2010

    • Author(s)
      服部信孝
    • Organizer
      Joint German-Japanese Symposium
    • Place of Presentation
      Juntendo University & Charite University, Berlin
    • Year and Date
      2010-10-13
  • [Presentation] SNCA三重複変異の同定2010

    • Author(s)
      舩山学、関根威、加賀谷肇、李元哲、吉野浩代、富山弘幸、服部信孝
    • Organizer
      第4回パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京都
    • Year and Date
      2010-10-08
  • [Presentation] 黒質神経細胞死のメカニズムに迫る:家族性パーキンソン病からヒントを得て2010

    • Author(s)
      服部信孝
    • Organizer
      第53回神経内科懇話会
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2010-08-07
  • [Presentation] パーキンソン病の治療:私の処方.ランチョンセミナ-52010

    • Author(s)
      服部信孝
    • Organizer
      第28回日本神経治療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-07-15
  • [Presentation] DBSへの神経内科医師の関わり方2010

    • Author(s)
      下泰司
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
  • [Presentation] パーキンソン病の分子病態機序のブレークスルー2010

    • Author(s)
      服部信孝
    • Organizer
      第51回日本神経学会総会シンポジウム4
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-05-21
  • [Presentation] SNP chipによる家族性パーキンソン病のlinkage解析(続報)2010

    • Author(s)
      舩山学, 吉野浩代, 今道洋子, 李元哲, 松浦英治, 有村公良, 高嶋博, 野元三治, 富山弘幸, 水野美邦, 服部信孝
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
  • [Presentation] Parkinson's complex :パーキンソン病をone of neuropsychiatric disorderとして捉まえる2010

    • Author(s)
      服部信孝.演者
    • Organizer
      第51回日本神経病理学会・ランチェンセミナー3
    • Place of Presentation
      シェーンバッハ・サボー東京
    • Year and Date
      2010-04-24
  • [Presentation] The Pathogenesis of Parkinson's Disease : From Insights of Monogenic Familial Parkinson's Disease. Session 5-3 : MAbs for Parkinson and Epilepsy Diseases2010

    • Author(s)
      服部信孝
    • Organizer
      BIT Life Sciences' 2nd Annual International Congress of Antibodies
    • Place of Presentation
      中国
    • Year and Date
      2010-03-25
  • [Presentation] ポスターセッションディスカッサ2009

    • Author(s)
      服部信孝
    • Organizer
      第32回日本分子物学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2009-12-10
  • [Book] PARK 2 : Parkin Mutations Responsible for Familial Prakinson's Disease. Movement Disorders 42010

    • Author(s)
      Hattori N, Hatano T, Machida Y, Sato S, Kubo S

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Published: 2013-07-31  

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