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2011 Fiscal Year Final Research Report

Molecular mechanism of type 2 diabetes based on pancreatic-cell enriched transcription factors

Research Project

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Project/Area Number 21390281
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionKumamoto University

Principal Investigator

YAMAGATA Kazuya  熊本大学, 大学院・生命科学研究部, 教授 (70324770)

Co-Investigator(Kenkyū-buntansha) SENOKUCHI Takafumi  熊本大学, 大学院・生命科学研究部, 助教 (00530320)
HATTA Mitsutoki  熊本大学, 大学院・生命科学研究部, 助教 (30344518)
Project Period (FY) 2009 – 2011
Keywords糖尿病 / インスリン / 遺伝子 / 転写因子 / hepatocyte nuclear factor / β細胞
Research Abstract

Mutation in the gene encoding hepatocyte nuclear factor 4(HNF4) cause impaired insulin secretion and type 2 diabetes, but the molecular mechanism is unknown. In the present work, I found that Anks4b is a novel target gene of HNF4 in-cells. Furthermore, I also identified that Anks4b regulates the sensitivity of ER stress in-cells. This study revealed that HNF4 regulates ER stress in-cells through Anks4b expression.

  • Research Products

    (20 results)

All 2011 2010 2009 Other

All Journal Article (9 results) Presentation (9 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Clinical features of Japanese type 2 diabetics with insulinogenic index in normal range after treatment of glucotoxicity2011

    • Author(s)
      Iwahashi H, Akita E, Tokunaga A, Okita K, Horikawa Y, Imagawa A, Funahashi T, Shimomura I, Yamagata K
    • Journal Title

      Diabetol Int

      Volume: 2 Pages: 208-213

  • [Journal Article] Deficit of Lys-tRNA Modification by Cdkal1 Causes the Development of Type 2 Diabetes in Mice2011

    • Author(s)
      Wei F-Y, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, Matsui H, Atta M, Michiue H, Fontecave M, Yamagata K, Suzuki T, Tomizawa K
    • Journal Title

      J. Clin. Invest

      Volume: 121 Pages: 3598-3608

  • [Journal Article] Voltage-gated K^+channel KCNQ1 regulates insulin secretion in MIN6-cell line2011

    • Author(s)
      Yamagata K, Senokuchi T, Lu M, Takemoto M, Karim MF, Go C, Sato Y, Hatta M, Yoshizawa T, Araki E, Miyazaki J, Song W-J
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 407 Pages: 620-625

  • [Journal Article] Cellular hypoxia of pancreatic-cells due to high levels of oxygen consumption for insulin secretion in vitro2011

    • Author(s)
      Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M
    • Journal Title

      J Biol. Chem

      Volume: 286 Pages: 12524-12532

  • [Journal Article] Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1 null mice2011

    • Author(s)
      Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R, Yamagata K, Oike Y
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 3992-4002

  • [Journal Article] Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages2010

    • Author(s)
      Higuchi Y, Shiraki N, Yamane K, Qin Z, Mochitate K, Araki K, Senokuchi T, Yamagata K, Hara M, Kume K, Kume S
    • Journal Title

      J Cell Sci

      Volume: 123 Pages: 2733-2742

  • [Journal Article] Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes2010

    • Author(s)
      Kozawa J, Okita K, Imagawa A, Iwahashi H, Holst JJ, Yamagata K, Shimomura I
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 393 Pages: 410-413

  • [Journal Article] Glucose enhances collectrin protein expression in insulin-producing MIN6 cells2009

    • Author(s)
      Saisho K, Fukuhara A, Yasuda T, Sato Y, Fukui K, Iwahashi H, Imagawa A, Hatta M, Shimomura I, Yamagata K
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 389 Pages: 133-137

  • [Journal Article] Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreaticβ-cells

    • Author(s)
      Sato Y, Hatta M, Karim Fazlul, Sawa T, Wei F-W, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K
    • Journal Title

      J Biol. Chem

      Volume: (in press)

  • [Presentation] Analysis of a novel HNF4 target gene Anks4b in pancreaticβ-cells2011

    • Author(s)
      Yoshifumi Sato, Mitsutoki Hatta, Md. Fazlul Karim, Tatsuya Yoshizawa, Kazuya Yamagata
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-12-13
  • [Presentation] シンポジウム1「酸素センサーとシグナル応答」膵β細胞における低酸素ストレス2011

    • Author(s)
      山縣和也
    • Organizer
      第17回MPO研究会
    • Place of Presentation
      アークホテル熊本(熊本)
    • Year and Date
      2011-10-28
  • [Presentation] 2型糖尿病疾患感受性遺伝子KCNQ1によるインスリン分泌2011

    • Author(s)
      山縣和也
    • Organizer
      第49回日本糖尿病学会九州地方会
    • Place of Presentation
      アクロス福岡(博多)
    • Year and Date
      2011-10-14
  • [Presentation] 核小体因子SIRT7による糖脂質代謝制御2011

    • Author(s)
      山縣和也
    • Organizer
      第32回日本肥満学会淡路夢舞台国際会議場
    • Place of Presentation
      兵庫
    • Year and Date
      2011-09-24
  • [Presentation] 膵β細胞と低酸素ストレス2011

    • Author(s)
      山縣和也
    • Organizer
      第5回Diabetes Leading-edge Conferenceロイヤルオークホテル
    • Place of Presentation
      滋賀
    • Year and Date
      2011-08-07
  • [Presentation] NAD依存性脱アセチル化酵素SIRT7の糖代謝への関与の検討2011

    • Author(s)
      瀬ノ口隆文、郷知佐、吉澤達也、宮田敬士、Eva Bober、尾池雄一、荒木栄一、山縣和也
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2011-05-21
  • [Presentation] HIF-1αによる酸素消費の抑制は膵β細胞の細胞内低酸素を回避する2011

    • Author(s)
      佐藤叔史、今川彰久、山縣和也、下村伊一郎、井上正宏
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2011-05-21
  • [Presentation] 膵β細胞における新規HNF-4標的遺伝子Anks4bの機能解析BMB20102010

    • Author(s)
      八田光世、MD. Fazlul Karim、佐藤叔史、瀬ノ口隆文、山縣和也
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会大会
    • Place of Presentation
      神戸ポートピアホテル(兵庫)
    • Year and Date
      2010-12-07
  • [Presentation] Regulation of insulin secretion by HNF-4 transcription factor BMB20102010

    • Author(s)
      Kazuya Yamagata
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会大会
    • Place of Presentation
      神戸ポートピアホテル(兵庫)
    • Year and Date
      2010-12-07
  • [Book] 糖尿病ナビゲーター2010

    • Author(s)
      山縣和也, 他
    • Total Pages
      36-37
    • Publisher
      メヂィカルレビュー社
  • [Remarks]

    • URL

      http://srv02.medic.kumamoto-u.ac.jp/dept/biochem2/biochem2.html

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Published: 2013-07-31  

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