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2011 Fiscal Year Final Research Report

Regulation of cell-metabolism by cardiovascular hormones and the comprehensive application to metabolic syndrome.

Research Project

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Project/Area Number 21390286
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionKeio University

Principal Investigator

ITOH Hiroshi  慶應義塾大学, 医学部, 教授 (40252457)

Co-Investigator(Kenkyū-buntansha) NAKAE Jun  慶應義塾大学, 医学部, 特任准教授 (00344573)
WATANABE Mitsuhiro  慶應義塾大学, 医学部, 特任准教授 (10450842)
SONE Masakatsu  京都大学, 大学院・医学研究科, 助教 (40437207)
Research Collaborator ICHIHARA Atsuhiro  東京女子医科大学, 医学部高血圧内分泌内科, 主任教授 (60203105)
SASAMURA Hiroyuki  慶應義塾大学, 医学部, 特任准教授 (00235293)
SHIBATA Hirotaka  慶應義塾大学, 医学部, 専任講師 (20245484)
WAKINO Shu  慶應義塾大学, 医学部, 専任講師 (50265823)
MIYASHITA Kazutoshi  慶應義塾大学, 医学部, 特任講師 (50378759)
Project Period (FY) 2009 – 2011
Keywords内分泌学 / 抗加齢医学 / 細胞代謝 / 心血管ホルモン / メタボリックシンドローム / FOXO1 / 胆汁酸 / iPS細胞
Research Abstract

Cardiovascular hormones control cytoskeletal structure in vascular smooth muscle cells and regulate vascular tonus. The present study revealed the regulation of cell-metabolism by cardiovascular hormones via modulation of intracellular organelles. The findings suggest comprehensive application of vascular hormones from the metabolic syndrome to cardiovascular diseases.

  • Research Products

    (13 results)

All 2012 2011 2010 2009 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (1 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor(FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure2011

    • Author(s)
      Watanabe M, Horai Y, Houten SM, Morimoto K, Sugizaki T, Arita E, Mataki C, Sato H, Tanigawara Y, Schoonjans K, H Itoh
    • Journal Title

      J Bio Chem

      Volume: 286(30) Pages: 26913-26920

    • Peer Reviewed
  • [Journal Article] (Pro) renin receptor is essential for normal podocyte structure and function2011

    • Author(s)
      Oshima Y, Kinouchi K, Ichihara A, Sakoda M, Kurauchi-Mito A, Bokuda K, Narita T, Kurosawa H, Ge-Hong Sun-Wada, Wada Y, Yamada T, Takemoto M, Moin A. Saleem, Susan E. Quaggin, H Itoh
    • Journal Title

      Journal of the American Society of Nephrology

      Volume: 22(12) Pages: 2203-12

    • Peer Reviewed
  • [Journal Article] Rho/Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch2011

    • Author(s)
      Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, H Itoh
    • Journal Title

      Sci Signal

      Volume: 4(157) Pages: 3

    • Peer Reviewed
  • [Journal Article] The(Pro) rennin Receptor/ATP6AP2 is Essential for Vascuolar H+-ATPase Assembly in Murine Cardiomyocytes2010

    • Author(s)
      K Kinouchi, A Ichihara, M Sano, Ge-Hong Sun-Wada, Y Wada, A Kurauchi-Mito, K Bokuda, T Narita, Y Oshima, M Sakoda, Y Tamai, H Sato, K Fukuda, H Itoh
    • Journal Title

      Circ Res

      Volume: 107 Pages: 30-34

    • Peer Reviewed
  • [Journal Article] Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function2010

    • Author(s)
      K. Hasegawa, S Wakino, K Yoshioka, S Tatematsu, Y Hara, H Minakuchi, K Sueyasu, N Washida, H Tokuyama, M Tzukerman, K Skorecki, K Hayashi, H Itoh
    • Journal Title

      J Biol Chem

      Volume: 285(17) Pages: 13045-13056

    • Peer Reviewed
  • [Journal Article] Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells2010

    • Author(s)
      Homma K, Sone M, Taura D, Yamahara K, Suzuki Y, Takahashi K, Sonoyama T, Inuzuka M, Fukunaga Y, Tamura N, H Itoh, Yamanaka S, Nakao K
    • Journal Title

      Atherosclerosis

      Volume: 212(1) Pages: 42-7

    • Peer Reviewed
  • [Journal Article] Induction and isolation of vascular cells from human induced pluripotent stem cells-brief report2009

    • Author(s)
      Taura D, Sone M, Homma K, Oyamada N, Takahashi K, Tamura N, Yamanaka S, Nakao K
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 29(7) Pages: 1100-3

    • Peer Reviewed
  • [Journal Article] Pulse treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension2009

    • Author(s)
      K. Ishiguro, K. Hayashi, H. Sasamura, Y. Sakamaki, H Itoh
    • Journal Title

      Hypertension

      Volume: 53 Pages: 83-89

    • Peer Reviewed
  • [Journal Article] Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity2009

    • Author(s)
      Miyashita K, Itoh H, Tsujimoto H, Tamura N, Fukunaga Y, Sone M, Yamahara K, Taura D, Inuzuka M, Sonoyama T, Nakao K
    • Journal Title

      Diabetes

      Volume: 58(12) Pages: 2880-92

    • Peer Reviewed
  • [Presentation] 高血圧の成因、病態、治療に関するパラダイムシフト細胞内小器官とアンジオテンシン細胞内代謝モデュレーターとしての意義2011

    • Author(s)
      伊藤裕
    • Organizer
      第34回日本高血圧学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2011-11-25
  • [Book] 最新内分泌代謝学高血圧・血管と内分泌総論2012

    • Author(s)
      宮下和季、伊藤裕
    • Publisher
      診断と治療社(印刷中)
  • [Remarks]

    • URL

      http://www.keio-emn.jp/

  • [Patent(Industrial Property Rights)] 慢性腎臓病判定用血清マーカーおよびその検出方法、装置2009

    • Inventor(s)
      篠村裕之、林香、伊藤裕、末松誠、曽我朋義
    • Industrial Property Rights Holder
      篠村裕之、林香、伊藤裕、末松誠、曽我朋義
    • Industrial Property Number
      特願、2009-206717号
    • Filing Date
      2009-08-17

URL: 

Published: 2013-07-31  

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