2011 Fiscal Year Final Research Report
Studies on Molecular-Cellular Mechanisms of Protein C Anticoagulant Pathway Crucial for Life Homeostasis
| Project/Area Number |
21390292
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Suzuka University of Medical Science (2011)
Mie University (2009-2010) |
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Principal Investigator |
SUZUKI Koji 鈴鹿医療科学大学, 薬学部, 教授 (70077808)
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| Co-Investigator(Kenkyū-buntansha) |
DEYASHIKI Yoshihiro 鈴鹿医療科学大学, 薬学部, 教授 (00202193)
HAYASHI Tatsuya 三重県立看護大学, 教授 (00242959)
OKAMOTO Takayuki 三重大学, 医学系研究科, 助教授 (30378286)
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| Project Period (FY) |
2009 – 2011
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| Keywords | プロテインC / プロテインS / トロンボモジュリン / C4b結合タンパク質 / 血管内皮細胞 / 細胞間ギャップ結合 / コネキシン32 / 血栓症 |
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| Research Abstract |
We studied the molecular-cellular mechanism of anticoagulant protein C pathway which is crucial for life homeostasis. The results obtained in the research are as follows. (1) Lipopolysaccharide-Toll-like receptor-mediated signaling regulates expression of protein S and C4b-binding protein in the liver. (2) The multi-functional serine protease inhibitor, protein C inhibitor regulates many organ functions beyond thrombosis and hemostasis. (3) Cellular gap junction molecule, connexin32 protects against vascular inflammation by modulating inflammatory cytokine expression by endothelial cells.
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