2011 Fiscal Year Final Research Report
Roles of bone marrow-derived cells in pathogenesis of pulmonary arterial hypertension associated with connective tissue diseases
| Project/Area Number |
21390300
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SETA Noriyuki 慶應義塾大学, 医学部, 助教 (40338372)
SATOH Takashi 北里大学, 医療衛生学部, 助教 (90407114)
FURUYA Yoshiaki 慶應義塾大学, 医学部, 助教 (30424154)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 膠原病学 |
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| Research Abstract |
Pulmonary arterial hypertension(PAH) associated with systemic sclerosis(SSc) is one of intractable conditions with poor prognosis, but its pathogenic process is largely unknown. We have examined potential roles of endothelial progenitor cells(EPCs), which are involved in vascular repair, in the pathogenesis of PAH associated with SSc. As a result, EPCs in patients with SSc exhibited impaired vascular repair machinery, but had enhanced pro-fibrotic capacity. These EPC properties are the most prominent in SSc patients with PAH, and invasion capacity is augmented in EPCs derived from such patients. In summary, aberrant circulating EPC is a novel therapeutic target in PAH associated with SSc.
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