A negative feedback mechanism controled by IL-33 and mast cells.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390303
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: SAITO Hirohisa 独立行政法人国立成育医療研究センター, 研究所, 副所長 (40130166)
• Co-Investigator(Kenkyū-buntansha): OBOKI Keisuke 独立行政法人国立成育医療研究センター, 研究所免疫アレルギー研究部, 上級研究員 (80415108) ; NAKAE Susumu 東京大学, 医科学研究所, 特任准教授 (60450409)
• Project Period (FY): 2009 – 2011
• Keywords: マスト細胞 / IL-33 / アレルギー・ぜんそく

Research Abstract

IL-33 is considered to be one of the important cytokines in asthma pathobiology. We uncovered the role of IL-33 in airway inflammation using newly developed IL-33 deficient mice.

Research Products

• [Journal Article] Omalizumab inhibits acceleration of FcεRI-mediated responsiveness of imamtu-re human mast cells by immunoglobulin E (2012)
  • Author(s): Okayama Y, Saito, H,(8番目) Ra C., et al
  • Journal Title: Ann Allergy Asthma Immunol Volume: 108(3) Pages: 188-94
  • DOI: DOI:10.1016/j.anai.2012.01.009
• [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice (2012)
  • Author(s): Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
  • Journal Title: Allergol Int Volume: 61(2) Pages: 265-73
  • DOI: DOI:10.2332/allergolint.11-OA-0379
• [Journal Article] The alarmin interleukin-33 drives protective antiviral CD8^+T cell responses (2012)
  • Author(s): Bonilla WV, Nakae, S,(12番目) Pinschewer DD., et al
  • Journal Title: Science Volume: 335(6071) Pages: 984-9
  • DOI: DOI:10.1126/science.1215418
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi M, Oboki, K,(8番目) Nakae, S,(12番目) Kubo M
  • Journal Title: J Immunol Volume: 188(4) Pages: 1809-18
  • DOI: DOI:10.4049/jimmunol.1101746
• [Journal Article] Interleukin-17A is involved in enhan-cement of tumor progression in murine intestine (2012)
  • Author(s): Oshiro K, Nakae, S,(8番目) Matsuzaki G., et al
  • Journal Title: Immunobiology Volume: 217(1) Pages: 54-60
  • DOI: DOI:10.1016/j.imbio.2011.08.002
• [Journal Article] Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model (2011)
  • Author(s): Kimura N, Itoh S, Nakae, S,(3番目) Fischbein MP., et al
  • Journal Title: J Heart Lung Transplant Volume: 30(12) Pages: 1409-17
  • DOI: DOI:10.1016/j.healun.2011.08.017
• [Journal Article] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity (2011)
  • Author(s): Otsuka A, Nakae, S,(10番目) Kabashima K., et al
  • Journal Title: PLoS One Volume: 6(9) Pages: e25538
  • DOI: DOI:10.1371/journal.pone.0025538
• [Journal Article] Interleukin-17 accelerates allograft rejection by suppress-ing regulatory T cell expansion (2011)
  • Author(s): Itoh S, Saito, H,(12番目) Nakae, S,(17番目) Fischbein MP., et al
  • Journal Title: Circulation Volume: 124(11) Pages: S187-96
  • DOI: DOI:10.1161/CIRCULATIONAHA.110.014852
• [Journal Article] Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations (2011)
  • Author(s): Noguchi E, Saito, H(33番目), Matsumoto K., et al
  • Journal Title: PLoS Genet Volume: 7(7) Pages: 1002170
  • DOI: DOI:10.1371/journal.pgen.1002170
• [Journal Article] N-acetylglucosaminyltransferase V-deficiency increases susceptibility to mur-ine malaria (2011)
  • Author(s): Shibui A, Nakae, S,(9番目) Hozumi N., et al
  • Journal Title: Exp Parasitol Volume: 129(3) Pages: 318-21
  • DOI: DOI:10.1016/j.exppara.2011.07.003
• [Journal Article] Human eosinophils produce and release a novel chemokine, CCL23, in vitro (2011)
  • Author(s): Matsumoto K, Fukuda S, Hashimoto N, Saito, H
  • Journal Title: Int Arch Allergy Immunol Volume: 155 Pages: 34-9
  • DOI: DOI:10.1159/000327263
• [Journal Article] Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro (2011)
  • Author(s): Iikura K, Katsunuma T, Saika S, Saito S, Ichinohe S, Ida H, Saito, H, Matsumoto K
  • Journal Title: Int Arch Allergy Immunol Volume: 155 Pages: 27-33
  • DOI: DOI:10.1159/000327262
• [Journal Article] Memory/effector(CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology (2011)
  • Author(s): Kamanaka M, Nakae, S,(8番目) Flavell RA., et al
  • Journal Title: J Exp Med Volume: 208(5) Pages: 1027-40
  • DOI: DOI:10.1084/jem.20102149
• [Journal Article] Cimetidine enhances antigen-specific IgE and Th2 cytokine production (2011)
  • Author(s): Arae K, Oboki, K, Ohno T, Hirata M, Nakae, S, Taguchi H, Saito, H, Nakajima T
  • Journal Title: Allergol Int Volume: 60(3) Pages: 339-44
  • DOI: DOI:10.2332/allergolint.10-OA-0255
• [Journal Article] Alterati-on of immune responses by N-acetylgluco-saminyltransferase V during allergic air-way inflammation (2011)
  • Author(s): Shibui A, Nakae, S.(last), et al
  • Journal Title: Allergol Int Volume: 60(3) Pages: 345-54
  • DOI: DOI:10.2332/allergolint.10-OA-0283
• [Journal Article] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation (2011)
  • Author(s): Ohno T, Oboki, K, Morita H, Kajiwara N, Arae K, Tanaka S, Ikeda M, Iikura M, Akiyama T, Inoue J, Matsumoto K, Sudo K, Azuma M, Okumura K, Kamradt T, Saito, H, Nakae, S
  • Journal Title: PLoS One Volume: 6(4) Pages: 18404
  • DOI: DOI:10.1371/journal.pone.0018404
• [Journal Article] Increased production of vascular endothe-lial growth factor-d and lymphangio-genesis in acute Kawasaki disease (2011)
  • Author(s): Ebata R, Saito, H,(7番目) Kohno Y., et al
  • Journal Title: Circ J Volume: 75(6) Pages: 1455-62
• [Journal Article] IL-33 and Airway Inflammation (2011)
  • Author(s): Oboki, K, Nakae, S, Matsumoto K, Saito, H
  • Journal Title: Allergy Asthma Immunol Res Volume: 3(2) Pages: 81-8
  • DOI: DOI:10.4168/aair.2011.3.2.81
• [Journal Article] Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils (2011)
  • Author(s): Suzukawa M, Nakae S,(8番目) Ohta K., et al
  • Journal Title: J Immunol Volume: 186(9) Pages: 5254-60
  • DOI: DOI:10.4049/jimmunol.1004054
• [Journal Article] Four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms (2011)
  • Author(s): Nomura I, Saito, H,(14番目) Matsumoto K., et al
  • Journal Title: J Allergy Clin Immunol Volume: 127(3) Pages: 685-8, e1-8
  • DOI: DOI:10.1016/j.jaci.2011.01.019
• [Journal Article] Functional specialization of interleukin-17 family members (2011)
  • Author(s): Iwakura Y, Ishigame H, Saijo S, Nakae, S
  • Journal Title: Immunity Volume: 34(2) Pages: 149-62
  • DOI: DOI:10.1016/j.immuni.2011.02.012
• [Journal Article] Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines (2011)
  • Author(s): Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito, H, Ikeda S, Ogawa H, Okumura K
  • Journal Title: Immunology Volume: 132(4) Pages: 527-39
  • DOI: DOI:10.1111/j.1365-2567.2010.03395.x
• [Journal Article] Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithet-lial cells (2011)
  • Author(s): Yamada Y, Saito, H.(last), et al
  • Journal Title: Int Arch Allergy Immunol Volume: 154(3) Pages: 185-94
  • DOI: DOI:10.1159/000321105
• [Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma (2011)
  • Author(s): Harada M, Saito, H,(21番目) Tamari M., et al
  • Journal Title: Am J Respir Cell Mol Biol Volume: 44(6) Pages: 787-93
  • DOI: DOI:10.1165/rcmb.2009-0418OC
• [Journal Article] Identification of a polyI : C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation (2010)
  • Author(s): Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito, H, Taniguchi T, Matsumoto M, Seya T
  • Journal Title: J Exp Med Volume: 207(12) Pages: 2675-87
  • DOI: DOI:10.1084/jem.20091573
• [Journal Article] Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits (2010)
  • Author(s): Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito, H, Tsuji K, Sekiya I
  • Journal Title: Arthritis Res Ther Volume: 12(6) Pages: 206
  • DOI: DOI:10.1186/ar3182
• [Journal Article] Phosphodiesterase 4B is essential for Th2-cell function and development of airway hyperresponsiveness in allergic asthma (2010)
  • Author(s): Jin SL, Nakae, S,(3番目) Conti M., et al
  • Journal Title: J Allergy Clin Immunol Volume: 126(6) Pages: 1252-9, e12
  • DOI: DOI:10.1016/j.jaci.2010.08.014
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity (2010)
  • Author(s): Oboki, K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito, H, Nakae, S
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107(43) Pages: 18581-6
  • DOI: DOI:10.1073/pnas.1003059107
• [Journal Article] IL-33 mediates inflammatory responses in human lung tissue cells (2010)
  • Author(s): Yagami A, Saito, H,(7番目) Matsuda A., et al
  • Journal Title: J Immunol Volume: 185(10) Pages: 5743-50
  • DOI: DOI:10.4049/jimmunol.0903818
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression (2010)
  • Author(s): Ishii A, Oboki, K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito, H, Nakae, S
  • Journal Title: Allergol Int Volume: 59(4) Pages: 399-408
  • DOI: DOI:10.2332/allergolint.10-OA-0218
• [Journal Article] Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition (2010)
  • Author(s): Takeichi T, Saito, H,(10番目) Tomita Y., et al
  • Journal Title: J Invest Dermatol Volume: 130(12) Pages: 2760-7
  • DOI: DOI:10.1038/jid.2010.203
• [Journal Article] TNF, but not IL-6 and IL-17, is crucial for the develop-ment of T cell-independent psoriasis-like dermatitis in Il1rn-/-mice (2010)
  • Author(s): Nakajima A, Nakae, S,(6番目) Iwakura Y., et al
  • Journal Title: J Immunol Volume: 185(3) Pages: 1887-93
  • DOI: DOI:10.4049/jimmunol.1001227
• [Journal Article] Altered effector CD4+T cell function in IL-21R-/-CD4+T cell-mediated graft-vers us-host disease (2010)
  • Author(s): Oh I, Nakae, S,(10番目) Ozawa K., et al
  • Journal Title: J Immunol Volume: 185(3) Pages: 1920-6
  • DOI: DOI:10.4049/jimmunol.0902217
• [Journal Article] Amphire-gulin is not essential for induction of contact hypersensitivity (2010)
  • Author(s): Yagami A, Oboki, K,(3番目) Saito, H,(9番目) Nakae, S.(last), et al
  • Journal Title: Allergol Int Volume: 59(3) Pages: 277-84
  • DOI: DOI:10.2332/allergolint.09-OA-0149
• [Journal Article] Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis (2010)
  • Author(s): Matsumoto K, Terakawa M, Fukuda S, Saito, H
  • Journal Title: Int Arch Allergy Immunol Volume: 152 Pages: 2-8
  • DOI: DOI:10.1159/000312119
• [Journal Article] Amphiregulin is not essential for ovalbumin-induced acute airway inflamma tion in mice (2010)
  • Author(s): Kajiwara N, Oboki, K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito, H, Nakae, S
  • Journal Title: Allergol Int Volume: 59(2) Pages: 207-11
  • DOI: DOI:10.2332/allergolint.09-OA-0144
• [Journal Article] IL-33 and IL-33 receptors in host defense and diseases (2010)
  • Author(s): Oboki, K, Ohno T, Kajiwara N, Saito, H, Nakae, S
  • Journal Title: Allergol Int Volume: 59(2) Pages: 143-60
  • DOI: DOI:10.2332/allergolint.10-RAI-0186
• [Journal Article] IL-1 and Allergy (2010)
  • Author(s): Nambu A, Nakae, S
  • Journal Title: Allergol Int Volume: 59(2) Pages: 125-35
  • DOI: DOI:10.2332/allergolint.10-RAI-0190
• [Journal Article] Activation of human mast cells through the platelet-activating factor receptor (2010)
  • Author(s): Kajiwara N, Saito, H,(7番目), Okayama Y
  • Journal Title: J Allergy Clin Immunol Volume: 125(5) Pages: 1137-1145
  • DOI: DOI:10.1016/j.jaci.2010.01.056
• [Journal Article] Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung (2010)
  • Author(s): Okamoto Yoshida Y, Nakae, S,(10番目), Matsuzaki G., et al
  • Journal Title: J Immunol Volume: 184(8) Pages: 4414-22
  • DOI: DOI:10.4049/jimmunol0903332
• [Journal Article] Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells (2010)
  • Author(s): Niyonsaba F, Saito, H,(8番目) Okumura K., et al
  • Journal Title: J Immunol Volume: 184(7) Pages: 3526-34
  • DOI: DOI:10.4049/jimmunol.0900712
• [Journal Article] Cells of extraembryonic mesodermal origin confer human dystro-phin in the mdx model of Duchenne muscular dystrophy (2010)
  • Author(s): Kawamichi Y, Saito, H,(8番目) Umezawa A., et al
  • Journal Title: J Cell Physiol Volume: 223(3) Pages: 695-702
  • DOI: DOI:10.1002/jcp.22076
• [Journal Article] The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice (2010)
  • Author(s): Itoh S, Nakae, S,(2番目) Fischbein MP., et al
  • Journal Title: J Heart Lung Transplant Volume: 29(4) Pages: 401-9
  • DOI: DOI:10.1016/j.healun.2009.08.019
• [Presentation] IL-33 in airway inflammation (2011)
  • Author(s): 大保木啓介
  • Organizer: APAPARI 2010 & 第48回JASPACI(第16回アジア太平洋小児アレルギー呼吸器免疫学会、第48回日本小児アレルギー学会合同大会)
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-29
• [Book] 粘膜における自然免疫:マスト細胞・好酸球・好塩基球,臨床粘膜免疫 (2010)
  • Author(s): 斎藤博久,大保木啓介,中江進,烏山一
  • Total Pages: 79-88
  • Publisher: シナジー、東京