• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Developent of glycolipid vaccines against tuberculos is

Research Project

  • PDF
Project/Area Number 21390304
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Infectious disease medicine
Research InstitutionKyoto University

Principal Investigator

SUGITA Masahiko  京都大学, ウイルス研究所, 教授 (80333532)

Co-Investigator(Kenkyū-buntansha) HARASHIMA Hideyoshi  北海道大学, 薬学研究科・研究院, 教授 (00183567)
MATSUNAGA Isamu  京都大学, ウイルス研究所, 准教授 (00254425)
Project Period (FY) 2009 – 2011
Keywords細菌 / 感染症 / 脂質 / 免疫学 / 結核
Research Abstract

Glucose monomycolate that pathogenic mycobacteria biosynthesize by utilizing host-derived glucose was tested for its ability to induce specific T cell responses in guinea pigs. It was shown for the first time that the glycolipid species was capable of eliciting delayed-type hypersensitivity in sensitized animals. Furthermore, the glucose monomycolate-induced T cell response was highly skewed to the production of the protective TH1-type cytokines. Thus, these results underscored the possibility that glucose monomycolate could function as a novel type of anti-tuberculosis vaccines.

  • Research Products

    (5 results)

All 2011 2010 Other

All Journal Article (2 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity2011

    • Author(s)
      Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
    • Journal Title

      J. Biol. Chem

      Volume: 286(19) Pages: 16800-16806

  • [Journal Article] Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs. Biochem2011

    • Author(s)
      Hattori Y, Matsunaga I, Komori T, UrakawaT, Nakamura T, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
    • Journal Title

      Biophys. Res. Commun

      Volume: 409(2) Pages: 304-307

  • [Presentation] 結核菌脂質を標的とした新しい免疫応答2010

    • Author(s)
      杉田昌彦
    • Organizer
      第53回日本感染症学会中日本地方会学術総会
    • Place of Presentation
      京都
    • Year and Date
      20101112-13
  • [Presentation] ミコール酸含有糖脂質の生合成と免疫認識~抗酸菌バイオロジーの新たな世界2010

    • Author(s)
      杉田昌彦
    • Organizer
      第85回日本結核病学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      20100520-21
  • [Remarks]

    • URL

      http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi