2011 Fiscal Year Final Research Report
Developent of glycolipid vaccines against tuberculos is
| Project/Area Number |
21390304
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARASHIMA Hideyoshi 北海道大学, 薬学研究科・研究院, 教授 (00183567)
MATSUNAGA Isamu 京都大学, ウイルス研究所, 准教授 (00254425)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細菌 / 感染症 / 脂質 / 免疫学 / 結核 |
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| Research Abstract |
Glucose monomycolate that pathogenic mycobacteria biosynthesize by utilizing host-derived glucose was tested for its ability to induce specific T cell responses in guinea pigs. It was shown for the first time that the glycolipid species was capable of eliciting delayed-type hypersensitivity in sensitized animals. Furthermore, the glucose monomycolate-induced T cell response was highly skewed to the production of the protective TH1-type cytokines. Thus, these results underscored the possibility that glucose monomycolate could function as a novel type of anti-tuberculosis vaccines.
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Research Products
(5 results)
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[Journal Article] Glycerol monomycolate, a latent tuberculosis-associated mycobacterial lipid, induces eosinophilic hypersensitivity responses in guinea pigs. Biochem2011
Author(s)
Hattori Y, Matsunaga I, Komori T, UrakawaT, Nakamura T, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
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Journal Title
Biophys. Res. Commun
Volume: 409(2)
Pages: 304-307
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