2011 Fiscal Year Final Research Report
Association of regulatory T cells to etiology of children with aplastic anemia
| Project/Area Number |
21390309
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
KOJIMA Seiji 名古屋大学, 大学院・医学系研究科, 教授 (20313992)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Yoshiyuki 名古屋大学, 医学系研究科, 准教授 (40432273)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Haruhiko 名古屋大学, 医学系研究科, 准教授 (90283431)
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| Project Period (FY) |
2009 – 2011
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| Keywords | Aplastic anemia / regulatory T cell / antithymocyte globulin |
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| Research Abstract |
We investigated the number of Tregs in children with alpastic anemia before and after IST or SCT. Fifty children with severe and very severe AA were enrolled in this study from 2007 to 2010. Surface CD4, CD25 and intracellular FOXP3 expression were examined in peripheral blood mononuclear cells by 3-color flow cytometry. The number of CD4+ CD25+ FOXP3+ Tregs is significantly decreased in patients at diagnosis as compared with normal control. The number of Tregs were significantly increased either after IST or after SCT.
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Research Products
(33 results)
