2012 Fiscal Year Final Research Report
Septin functions and autistic spectrum disorder/pervasive developmental disorders during neuronal development
| Project/Area Number |
21390318
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
NAGATA Koh-ichi 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 部長 (50252143)
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| Co-Investigator(Renkei-kenkyūsha) |
INAGUMA Yutaka 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (10250250)
ITO Hidenori 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (40311443)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 小児神経学 |
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| Research Abstract |
Sept14 is strongly expressed in the cortical plate of developing cerebral cortex, suggesting its pathophysiological role in developmental disorders. We thus screened binding partners for Sept14 and Sept4. Affinity chromatography combined with shotgun LC-MS/MS revealed that many proteins functioning in the cytoskeleton regulation interact with these septins. We are focusing on several molecules, of which involvement in neuronal cell migration has been reported, such as coffilin, drebrin and filamin.
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Research Products
(22 results)
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[Journal Article] Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats.2011
Author(s)
Hamatake M, Miyazaki N, Sudo K, Matsuda M, Sadakata T, Furuya A, Ichisaka S, Hata Y, Nakagawa C, Nagata K, Furuichi T, Katoh-Semba R
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Journal Title
J. Biol. Chem.
Volume: 286
Pages: 21478-21487
DOI
Peer Reviewed
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[Journal Article] TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.2009
Author(s)
Iguchi Y, Katsuno M, Niwa J, Yamada S, Sone J, Waza M, Adachi H, Tanaka F, Nagata K, Arimura N, Watanabe T, Kaibuchi K, Sobue G
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Journal Title
J. Biol. Chem.
Volume: 284
Pages: 22059-22066
DOI
Peer Reviewed
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