2012 Fiscal Year Final Research Report
Cellular signaling system in Psoriatic epidermis
| Project/Area Number |
21390323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
IIZUKA Hajime 旭川医科大学, 医学部, 教授 (90113513)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Akemi 旭川医科大学, 医学部, 准教授 (30241441)
TAKAHASHI Hiswtoshi 旭川医科大学, 医学部, 講師 (00216748)
HONMA Masaru 旭川医科大学, 医学部, 講師 (50344578)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 乾癬 / 表皮細胞 / 細胞内情報伝達 / ポドプラニン / IL-22 |
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| Research Abstract |
Podoplanin expression of keratinocytes was induced by IL-22 in a STAT-3-dependent manner. The podoplanin expression was highly upregulated in basal cells of granular layer-negative psoriatic epidermis compared with that of granular layer positive less hyperproliferative epidermis. Furthermore, podoplanin expression was more marked on basal cells of psoriatic rete ridges where stem cell-derived transit amplifying cells are assumed to be located. The finite proliferative potential of transit amplifying cells was confirmed in keratinocyte following podoplanin induction. These results indicate that podoplanin might be a novel marker of transit amplifying cells of epidermis.
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